{"title":"ABclonal","description":"","products":[{"product_id":"new-product-754889","title":"Human Collagen Type III (Col III) ELISA Kit","description":"","brand":"Abclonal","offers":[{"title":"Default Title","offer_id":44924475375840,"sku":"RK04960","price":0.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814304","title":"TLR4 Rabbit pAb","description":"\u003cp\u003eThe protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092010684640,"sku":"A0007","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814303","title":"Tau Rabbit pAb","description":"\u003cp\u003eThis gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092010324192,"sku":"A0002","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814305","title":"PTEN Rabbit pAb","description":"\u003cp\u003eThis gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT\/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092010717408,"sku":"A0008","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814307","title":"Cytokeratin 4 (KRT4) Rabbit mAb","description":"\u003cp\u003eThe protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092010848480,"sku":"A0013","price":368.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814306","title":"PARP1 Rabbit pAb","description":"\u003cp\u003eThis gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092010782944,"sku":"A0010","price":368.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814308","title":"Ret Rabbit pAb","description":"\u003cp\u003eThis gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092010881248,"sku":"A0018","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814310","title":"KAT9\/Elp3 Rabbit mAb","description":"\u003cp\u003eEnables acetyltransferase activity and phosphorylase kinase regulator activity. Involved in regulation of transcription by RNA polymerase II and tRNA wobble uridine modification. Located in cytosol and nucleolus. Part of elongator holoenzyme complex.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092011077856,"sku":"A0020","price":368.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814309","title":"Caspase-9 Rabbit pAb","description":"\u003cp\u003eThis gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092010914016,"sku":"A0019","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814315","title":"B-Raf Rabbit pAb","description":"\u003cp\u003eThis gene encodes a protein belonging to the RAF family of serine\/threonine protein kinases. This protein plays a role in regulating the MAP kinase\/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092011241696,"sku":"A0038","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814312","title":"Tyrosine Hydroxylase Rabbit pAb","description":"\u003cp\u003eThe protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092011143392,"sku":"A0028","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814314","title":"STIP1 Rabbit mAb","description":"\u003cp\u003eSTIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092011208928,"sku":"A0036","price":368.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814311","title":"STAT1 Rabbit pAb","description":"\u003cp\u003eThe protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092011110624,"sku":"A0027","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814313","title":"Formyl-Histone H2B-K108 Rabbit mAb","description":"\u003cp\u003eHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. The protein has antibacterial and antifungal antimicrobial activity.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092011176160,"sku":"A0032","price":368.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814316","title":"MET Rabbit pAb","description":"\u003cp\u003eThis gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092011274464,"sku":"A0040","price":298.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/A0040_1.jpg?v=1721946607"},{"product_id":"new-product-814320","title":"PI3 Kinase p85 alpha Rabbit pAb","description":"\u003cp\u003ePhosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092011438304,"sku":"A0054","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814317","title":"NQO1 Rabbit pAb","description":"\u003cp\u003eThis gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092011307232,"sku":"A0047","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814318","title":"MGMT Rabbit pAb","description":"\u003cp\u003eAlkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092011372768,"sku":"A0052","price":298.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/A0052_1.jpg?v=1721946617"},{"product_id":"new-product-814319","title":"Thioredoxin 1 (Trx1\/TXN) Rabbit pAb","description":"\u003cp\u003eThe protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092011405536,"sku":"A0053","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814322","title":"VEGFR1 Rabbit pAb","description":"\u003cp\u003eThis gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092011897056,"sku":"A0058","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814324","title":"CYP1A2 Rabbit pAb","description":"\u003cp\u003eThis gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092012847328,"sku":"A0062","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814321","title":"Prohibitin Rabbit pAb","description":"\u003cp\u003eThis gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092011765984,"sku":"A0056","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814325","title":"Formyl-Histone H2B-K120 Rabbit mAb","description":"\u003cp\u003eHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. The protein has antibacterial and antifungal antimicrobial activity.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092013240544,"sku":"A0065","price":368.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814323","title":"Caveolin-1 Rabbit pAb","description":"\u003cp\u003eThe scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42\/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092012126432,"sku":"A0059","price":298.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/A0059_1.jpg?v=1721946636"},{"product_id":"new-product-814328","title":"BCR Rabbit pAb","description":"\u003cp\u003eA reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine\/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092014059744,"sku":"A0068","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814327","title":"MMP14\/MT1-MMP Rabbit mAb","description":"\u003cp\u003eProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092013699296,"sku":"A0067","price":368.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814326","title":"KAT2B\/PCAF Rabbit pAb","description":"\u003cp\u003eCBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and\/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300\/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300\/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092013404384,"sku":"A0066","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814330","title":"KIFC1 Rabbit mAb","description":"\u003cp\u003ePredicted to enable microtubule binding activity and minus-end-directed microtubule motor activity. Involved in mitotic metaphase plate congression and mitotic spindle assembly. Located in membrane.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092014616800,"sku":"A0077","price":368.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814329","title":"Integrin beta 3 (ITGB3\/CD61) Rabbit pAb","description":"\u003cp\u003eThe ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092014452960,"sku":"A0076","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814335","title":"Perforin Rabbit pAb","description":"\u003cp\u003eThis gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092015698144,"sku":"A0093","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814333","title":"FGFR1 Rabbit pAb","description":"\u003cp\u003eThe protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092015304928,"sku":"A0082","price":298.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/A0082_1.jpg?v=1721946688"},{"product_id":"new-product-814334","title":"RANBP3 Rabbit mAb","description":"\u003cp\u003eThis gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092015436000,"sku":"A0092","price":368.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814332","title":"MonoMethyl-Histone H2B-K116 Rabbit mAb","description":"\u003cp\u003eHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. The protein has antibacterial and antifungal antimicrobial activity.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092015042784,"sku":"A0080","price":368.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814331","title":"FGF1 Rabbit pAb","description":"\u003cp\u003eThe protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092014911712,"sku":"A0079","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814336","title":"[KO Validated] CDK2 Rabbit mAb","description":"\u003cp\u003eThis gene encodes a member of a family of serine\/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092015861984,"sku":"A0094","price":368.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814339","title":"eEF2 Rabbit pAb","description":"\u003cp\u003eThis gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092016517344,"sku":"A0099","price":298.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/A0099_1.jpg?v=1721946711"},{"product_id":"new-product-814337","title":"CAST Rabbit pAb","description":"\u003cp\u003eThe protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain\/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092016025824,"sku":"A0097","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814340","title":"FOXO3A Rabbit pAb","description":"\u003cp\u003eEnables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and mitochondrial transcription factor activity. Involved in several processes, including mitochondrial transcription; positive regulation of muscle atrophy; and positive regulation of pri-miRNA transcription by RNA polymerase II. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; female gonad development; and neuronal stem cell population maintenance. Located in cytosol; mitochondrial outer membrane; and nucleus. Part of protein-containing complex. Colocalizes with mitochondrial matrix. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system. Used to study dermoid cyst of ovary. Orthologous to human FOXO3 (forkhead box O3).\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092016648416,"sku":"A0102","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814338","title":"SERCA2\/ATP2A2 Rabbit pAb","description":"\u003cp\u003eThis gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of the skeletal muscle. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction\/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Other types of mutations in this gene have been associated with various forms of muscular dystrophies. Alternative splicing results in multiple transcript variants encoding different isoforms.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092016124128,"sku":"A0098","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814341","title":"CDK6 Rabbit mAb","description":"\u003cp\u003eThe protein encoded by this gene is a member of the CMGC family of serine\/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1\/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092016877792,"sku":"A0106","price":368.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/A0106_1.jpg?v=1721946718"},{"product_id":"new-product-814344","title":"CCR7 Rabbit mAb","description":"\u003cp\u003eThe protein encoded by this gene is a member of the G protein-coupled receptor family.This receptor was identified as a gene induced by the Epstein-Barr virus (EBV),and is thought to be a mediator of EBV effects on B lymphocytes.This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes.It has been shown to control the migration of memory T cells to inflamed tissues,as well as stimulate dendritic cell maturation.The chemokine (C-C motif) ligand 19 (CCL19\/ECL) has been reported to be a specific ligand of this receptor.Signals mediated by this receptor regulate T cell homeostasis in lymph nodes,and may also function in the activation and polarization of T cells,and in chronic inflammation pathogenesis.Alternative splicing of this gene results in multiple transcript variants.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092017828064,"sku":"A0121","price":368.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814343","title":"GluR2\/GRIA2 Rabbit pAb","description":"Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG-\u0026gt;CGG; Q-\u0026gt;R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q\/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092017336544,"sku":"A0111","price":298.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/A0111_1.jpg?v=1721946727"},{"product_id":"new-product-814342","title":"MSP\/MST1 Rabbit mAb","description":"\u003cp\u003eThe protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092017008864,"sku":"A0109","price":368.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814345","title":"SHIP1 Rabbit pAb","description":"\u003cp\u003eThis gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Deficiencies in the encoded protein, SHIP1, have been associated with Inflammatory Bowel Disease types such as Crohn's Disease and Ulcerative Colitis. Alternative splicing of this gene results in multiple transcript variants.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092018024672,"sku":"A0122","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814346","title":"Cytokeratin 17 (KRT17) Rabbit pAb","description":"\u003cp\u003eThis gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092018155744,"sku":"A0123","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814347","title":"PBX1 Rabbit pAb","description":"\u003cp\u003eThis gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3\/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092018352352,"sku":"A0124","price":298.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/A0124_1.jpg?v=1721946746"},{"product_id":"new-product-814350","title":"PSD95 Rabbit mAb","description":"\u003cp\u003eThis gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092018843872,"sku":"A0131","price":368.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814348","title":"NCSTN Rabbit pAb","description":"\u003cp\u003eThis gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092018483424,"sku":"A0128","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814349","title":"LRP5 Rabbit pAb","description":"\u003cp\u003eThis gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092018745568,"sku":"A0130","price":298.0,"currency_code":"KRW","in_stock":true}]},{"product_id":"new-product-814354","title":"TRMT2A\/HTF9C Rabbit mAb","description":"\u003cp\u003eThe protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biomarker in certain breast cancers. Several transcript variants encoding two different isoforms have been found for this gene.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092019433696,"sku":"A0136","price":368.0,"currency_code":"KRW","in_stock":true}]}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/collections\/ABclonal-Technology.jpg?v=1721946597","url":"https:\/\/rndmate.com\/collections\/abclonal.oembed?page=1041","provider":"알앤디메이트","version":"1.0","type":"link"}