{"title":"Spirochrome","description":"\u003cdiv class=\"brand-page spirochrome\"\u003e\n\n  \u003c!-- Hero \/ Intro --\u003e\n  \u003csection id=\"spirochrome-hero\"\u003e\n    \u003ch1\u003eSpirochrome – Live-Cell Bioimaging Probes for Cytoskeleton \u0026amp; DNA\u003c\/h1\u003e\n    \u003cp\u003e\n      \u003cstrong\u003eSpirochrome\u003c\/strong\u003e는 스위스 Stein am Rhein에 본사를 둔\n      \u003cstrong\u003elive-cell bioimaging용 형광 프로브\u003c\/strong\u003e 전문 브랜드로,\n      \u003cstrong\u003eDNA, F-actin, microtubules, lysosome, Golgi, peroxisome\u003c\/strong\u003e 등\n      다양한 세포 구조를 \u003cstrong\u003e고해상도 실시간 영상화\u003c\/strong\u003e 할 수 있는\n      혁신적인 \u003cstrong\u003eSiR™ \/ SiR700™ \/ SPY™\u003c\/strong\u003e 프로브 포트폴리오를 제공합니다.\n    \u003c\/p\u003e\n    \u003cp\u003e\n      연구자는 복잡한 유전자 도입(transfection) 없이,\n      \u003cstrong\u003e“add and image” 프로토콜\u003c\/strong\u003e만으로 살아있는 세포에서\n      세포골격과 핵, 세포 소기관을 정밀하게 관찰할 수 있습니다.\n    \u003c\/p\u003e\n  \u003c\/section\u003e\n\n  \u003c!-- About --\u003e\n  \u003csection id=\"about-spirochrome\"\u003e\n    \u003ch2\u003e브랜드 소개 (About Spirochrome)\u003c\/h2\u003e\n    \u003cp\u003e\n      \u003cstrong\u003eSpirochrome AG\u003c\/strong\u003e는 2014년에 설립된 스위스 바이오텍 기업으로,\n      \u003cstrong\u003eprobes for bioimaging\u003c\/strong\u003e에 특화되어 있습니다.\n      살아있는 세포에서 세포골격과 세포 소기관을\n      \u003cstrong\u003e독성이 낮은 형광 프로브\u003c\/strong\u003e로 간편하게 염색하고,\n      \u003cstrong\u003econfocal, spinning disk, STED, SIM\u003c\/strong\u003e과 같은\n      고급 이미징 플랫폼에서 사용할 수 있는 제품을 개발해 왔습니다.\n    \u003c\/p\u003e\n    \u003cp\u003e\n      Spirochrome의 대표 제품군인 \u003cstrong\u003eSiR-actin, SiR-tubulin, SiR-DNA\u003c\/strong\u003e는\n      전 세계 수많은 논문과 이미지 데이터에서\n      \u003cstrong\u003efar-red, fluorogenic, cell-permeable probe\u003c\/strong\u003e의\n      새로운 기준으로 활용되고 있습니다.\n    \u003c\/p\u003e\n  \u003c\/section\u003e\n\n  \u003c!-- Technology --\u003e\n  \u003csection id=\"spirochrome-technology\"\u003e\n    \u003ch2\u003e핵심 기술 (Technology)\u003c\/h2\u003e\n\n    \u003ch3\u003e1. SiR™ (Silicon Rhodamine) 기반 Fluorogenic Probes\u003c\/h3\u003e\n    \u003cp\u003e\n      \u003cstrong\u003eSiR™ 프로브\u003c\/strong\u003e는 \u003cstrong\u003esilicon rhodamine\u003c\/strong\u003e 형광체를 기반으로 하며,\n      \u003cstrong\u003efar-red 영역(예: 652\/674 nm, 689\/716 nm 등)\u003c\/strong\u003e에서\n      여기·방출되는 특성을 가지고 있습니다.\n      이로 인해 세포 자가형광과 스펙트럼 간섭이 줄어들고,\n      \u003cstrong\u003ephototoxicity 최소화\u003c\/strong\u003e와 \u003cstrong\u003esignal-to-background 향상\u003c\/strong\u003e이 가능합니다.\n    \u003c\/p\u003e\n    \u003cul\u003e\n      \u003cli\u003e세포 투과성 (cell-permeable)\u003c\/li\u003e\n      \u003cli\u003e타깃 결합 시 밝아지는 \u003cstrong\u003efluorogenic\u003c\/strong\u003e 특성\u003c\/li\u003e\n      \u003cli\u003e높은 타깃 특이성 (F-actin, microtubules, DNA, lysosome 등)\u003c\/li\u003e\n      \u003cli\u003eCy5 \/ far-red 채널과 호환 → 다른 형광 단백질(GFP, mCherry 등)과 멀티컬러 이미징 용이\u003c\/li\u003e\n      \u003cli\u003eSTED, SIM과 같은 \u003cstrong\u003esuper-resolution microscopy\u003c\/strong\u003e와 호환\u003c\/li\u003e\n    \u003c\/ul\u003e\n\n    \u003ch3\u003e2. SPY™ Probes – 가시광 전 영역을 커버하는 Live-Cell Probes\u003c\/h3\u003e\n    \u003cp\u003e\n      \u003cstrong\u003eSPY™ probes\u003c\/strong\u003e는 SiR 계열의 장점을 유지하면서\n      \u003cstrong\u003eFITC, TMR, Texas Red\u003c\/strong\u003e 등 다양한 파장대(녹색~적색)의 채널을\n      활용할 수 있도록 확장한 시리즈입니다.\n      \u003cstrong\u003eSPY555-actin, SPY620-actin, SPY650-tubulin, SPY-DNA\u003c\/strong\u003e 등은\n      live-cell에서 actin, microtubules, DNA를\n      \u003cstrong\u003e밝고 안정적인 형광\u003c\/strong\u003e으로 표현해 줍니다.\n    \u003c\/p\u003e\n    \u003cul\u003e\n      \u003cli\u003eLive-cell에서 사용 가능한 fluorogenic probe\u003c\/li\u003e\n      \u003cli\u003ePhotostable \u0026amp; non-toxic → long-term imaging에 적합\u003c\/li\u003e\n      \u003cli\u003eSTED \/ SIM 호환 → 고해상도 구조 관찰 가능\u003c\/li\u003e\n      \u003cli\u003e여러 파장대 옵션으로 멀티컬러 패널 구성 용이\u003c\/li\u003e\n    \u003c\/ul\u003e\n\n    \u003ch3\u003e3. 차세대 특수 어플리케이션용 Probes\u003c\/h3\u003e\n    \u003cp\u003e\n      Spirochrome은 최근 \u003cstrong\u003eHAK-actin™\u003c\/strong\u003e과 같이\n      \u003cstrong\u003eU-ExM (Ultrastructure Expansion Microscopy)\u003c\/strong\u003e,\n      \u003cstrong\u003eCryo-ExM\u003c\/strong\u003e과 같은 \u003cstrong\u003eExpansion Microscopy\u003c\/strong\u003e에 최적화된\n      특수 프로브도 제공하여, 나노스케일 구조를\n      더욱 정밀하게 재현하는 연구에 활용되고 있습니다.\n    \u003c\/p\u003e\n  \u003c\/section\u003e\n\n  \u003c!-- Features --\u003e\n  \u003csection id=\"spirochrome-features\"\u003e\n    \u003ch2\u003e주요 특징 (Key Features)\u003c\/h2\u003e\n    \u003cul\u003e\n      \u003cli\u003e\n\u003cstrong\u003eFluorogenic\u003c\/strong\u003e – 타깃 구조에 결합했을 때 신호가 증가하여 background가 낮음\u003c\/li\u003e\n      \u003cli\u003e\n\u003cstrong\u003eCell-permeable\u003c\/strong\u003e – 살아있는 세포에 직접 첨가(add) 후 바로 관찰 가능\u003c\/li\u003e\n      \u003cli\u003e\n\u003cstrong\u003eNon- or low-toxic\u003c\/strong\u003e – long-term live-cell imaging에 적합\u003c\/li\u003e\n      \u003cli\u003e\n\u003cstrong\u003eNo genetic manipulation\u003c\/strong\u003e – transfection 없이 내인성 구조 관찰\u003c\/li\u003e\n      \u003cli\u003e\n\u003cstrong\u003eFar-red \/ Red \/ Green 채널 선택\u003c\/strong\u003e – 멀티컬러 실험 디자인 용이\u003c\/li\u003e\n      \u003cli\u003e\n\u003cstrong\u003eSuper-resolution 호환\u003c\/strong\u003e – STED, SIM, confocal, spinning disk, light-sheet 등과 호환\u003c\/li\u003e\n      \u003cli\u003e\n\u003cstrong\u003e간단한 프로토콜\u003c\/strong\u003e – “add \u0026amp; incubate \u0026amp; image” 형태의 쉬운 사용법\u003c\/li\u003e\n    \u003c\/ul\u003e\n  \u003c\/section\u003e\n\n  \u003c!-- Benefits \/ Why Spirochrome --\u003e\n  \u003csection id=\"spirochrome-benefits\"\u003e\n    \u003ch2\u003e장점 (Why Choose Spirochrome?)\u003c\/h2\u003e\n    \u003cul\u003e\n      \u003cli\u003e\n        \u003cstrong\u003e세포 생존력 유지\u003c\/strong\u003e  \n        낮은 phototoxicity와 독성으로, 장시간 타임랩스 실험과\n        live-cell tracking에 유리합니다.\n      \u003c\/li\u003e\n      \u003cli\u003e\n        \u003cstrong\u003e높은 재현성과 일관성\u003c\/strong\u003e  \n        최적화된 농도와 프로토콜로, 서로 다른 세포주 및 실험 간에도\n        안정된 형광 패턴을 유지합니다.\n      \u003c\/li\u003e\n      \u003cli\u003e\n        \u003cstrong\u003e멀티컬러 및 멀티타깃 적용\u003c\/strong\u003e  \n        actin, tubulin, DNA, lysosome, Golgi, peroxisome 등\n        다양한 구조를 동시에 라벨링하여 복잡한 세포 동역학을 분석할 수 있습니다.\n      \u003c\/li\u003e\n      \u003cli\u003e\n        \u003cstrong\u003e광학 장비와의 높은 호환성\u003c\/strong\u003e  \n        일반 widefield부터 confocal, STED, SIM까지\n        다양한 현미경 시스템과 함께 사용할 수 있도록 설계되었습니다.\n      \u003c\/li\u003e\n      \u003cli\u003e\n        \u003cstrong\u003eHigh-content \/ high-throughput imaging에 적합\u003c\/strong\u003e  \n        wash step을 최소화하고 간단한 add-only 프로토콜을 제공하여\n        자동화된 이미징 플랫폼에서도 효율적으로 사용 가능합니다.\n      \u003c\/li\u003e\n    \u003c\/ul\u003e\n  \u003c\/section\u003e\n\n  \u003c!-- Applications --\u003e\n  \u003csection id=\"spirochrome-applications\"\u003e\n    \u003ch2\u003e적용 분야 (Applications)\u003c\/h2\u003e\n    \u003cul\u003e\n      \u003cli\u003eLive-cell cytoskeleton imaging (F-actin, microtubules)\u003c\/li\u003e\n      \u003cli\u003eLive-cell nuclear \u0026amp; chromatin imaging (DNA \/ nucleus)\u003c\/li\u003e\n      \u003cli\u003eLysosome \/ Golgi \/ peroxisome 등 세포 소기관 추적\u003c\/li\u003e\n      \u003cli\u003eSuper-resolution microscopy (STED, SIM) 기반 세포 구조 연구\u003c\/li\u003e\n      \u003cli\u003eTime-lapse live-cell imaging \u0026amp; 동적 세포골격 분석\u003c\/li\u003e\n      \u003cli\u003ePrimary cells, sensitive cell lines에서의 낮은 독성 형광 라벨링\u003c\/li\u003e\n    \u003c\/ul\u003e\n  \u003c\/section\u003e\n\n  \u003c!-- Key Products --\u003e\n  \u003csection id=\"spirochrome-key-products\"\u003e\n    \u003ch2\u003e대표 제품 (Representative Product Lines)\u003c\/h2\u003e\n\n    \u003ch3\u003e1. SiR™ Probes – Far-Red Live-Cell Probes\u003c\/h3\u003e\n    \u003cul\u003e\n      \u003cli\u003e\n        \u003cstrong\u003eSiR-actin kit (SC001)\u003c\/strong\u003e  \n        F-actin에 특이적인 fluorogenic, cell-permeable probe로,\n        jasplakinolide 기반 actin ligand를 사용하여 내인성 actin을 고해상도로 라벨링합니다.\n      \u003c\/li\u003e\n      \u003cli\u003e\n        \u003cstrong\u003eSiR-tubulin kit (SC002)\u003c\/strong\u003e  \n        microtubules에 특이적인 live-cell probe로, dynamic microtubule 네트워크를\n        real-time으로 관찰할 수 있습니다.\n      \u003c\/li\u003e\n      \u003cli\u003e\n        \u003cstrong\u003eSiR-DNA kit (SC007)\u003c\/strong\u003e  \n        silicon rhodamine과 DNA minor groove binder(Hoechst 계열)를 결합한\n        live-cell DNA probe로, 핵 및 염색체 DNA를 낮은 background로 라벨링합니다.\n      \u003c\/li\u003e\n      \u003cli\u003e\n        \u003cstrong\u003eSiR-lysosome \/ SiR700-DNA \/ SiR700-actin \/ SiR700-tubulin\u003c\/strong\u003e  \n        보다 긴 파장대의 SiR700 계열 프로브로, deep imaging 및 multicolor 세팅에서\n        유리한 옵션을 제공합니다.\n      \u003c\/li\u003e\n    \u003c\/ul\u003e\n\n    \u003ch3\u003e2. SPY™ Probes – Visible Spectrum Live-Cell Probes\u003c\/h3\u003e\n    \u003cul\u003e\n      \u003cli\u003e\n        \u003cstrong\u003eSPY555-actin \/ SPY620-actin\u003c\/strong\u003e  \n        actin dynamics를 실시간으로 관찰할 수 있는 bright, fluorogenic live-cell actin probe로,\n        orange\/red 채널에서 강한 신호를 제공합니다.\n      \u003c\/li\u003e\n      \u003cli\u003e\n        \u003cstrong\u003eSPY650-tubulin \/ SPY700-tubulin\u003c\/strong\u003e  \n        microtubules용 far-red \/ near-IR live-cell probe로, 세포 내 microtubule 네트워크를\n        고감도·저배경으로 시각화합니다.\n      \u003c\/li\u003e\n      \u003cli\u003e\n        \u003cstrong\u003eSPY595-DNA \/ SPY620-DNA \/ SPY650-DNA \/ SPY700-DNA\u003c\/strong\u003e  \n        다양한 파장대 옵션을 제공하는 live-cell nuclear DNA stains로,\n        멀티컬러 실험에서 핵 신호를 안정적으로 확보할 수 있습니다.\n      \u003c\/li\u003e\n      \u003cli\u003e\n        \u003cstrong\u003eSPY650-FastAct™ \/ SPY700-FastAct™\u003c\/strong\u003e  \n        빠르게 변하는 actin dynamics를 포착할 수 있도록 설계된 고급 actin probe로,\n        dynamic 구조와 static 구조를 모두 안정적으로 라벨링하면서\n        독성과 F-actin 안정화 효과를 최소화합니다.\n      \u003c\/li\u003e\n    \u003c\/ul\u003e\n\n    \u003ch3\u003e3. Organelle \u0026amp; Membrane Probes\u003c\/h3\u003e\n    \u003cul\u003e\n      \u003cli\u003e\n        \u003cstrong\u003eSiR-lysosome \/ Lyso Flipper-TR\u003c\/strong\u003e  \n        lysosome 및 막 장력(membrane tension) 변화를 분석하기 위한 특수 probe로,\n        세포 스트레스, 오토파지, trafficking 연구에 활용됩니다.\n      \u003c\/li\u003e\n      \u003cli\u003e\n        \u003cstrong\u003eSPY650-Golgi \/ Peroxi_SPY650\u003c\/strong\u003e  \n        Golgi apparatus와 peroxisome 구조를 빠르게 라벨링하여,\n        15분 이내에 live-cell imaging을 시작할 수 있습니다.\n      \u003c\/li\u003e\n    \u003c\/ul\u003e\n\n    \u003ch3\u003e4. Expansion Microscopy \u0026amp; Advanced Applications\u003c\/h3\u003e\n    \u003cul\u003e\n      \u003cli\u003e\n        \u003cstrong\u003eHAK-actin™\u003c\/strong\u003e  \n        U-ExM 및 Cryo-ExM용 actin probe로,\n        expansion gel 내부에 actin 구조를 공유 결합 형태로 고정하여,\n        확장 후에도 정밀한 actin ultrastructure를 재현할 수 있도록 설계되었습니다.\n      \u003c\/li\u003e\n    \u003c\/ul\u003e\n  \u003c\/section\u003e\n\n  \u003c!-- CTA --\u003e\n  \u003csection id=\"spirochrome-cta\"\u003e\n    \u003ch2\u003e구매 및 기술 문의\u003c\/h2\u003e\n    \u003cp\u003e\n      Spirochrome 제품에 대한 \u003cstrong\u003e견적 문의, 재고 확인, 최적의 프로브 선택 상담\u003c\/strong\u003e이 필요하시면\n      아래 연락처로 문의해 주세요.  \n      실험 목적, 사용 장비, 타겟 구조에 맞추어 \u003cstrong\u003eSiR™ \/ SiR700™ \/ SPY™\u003c\/strong\u003e 제품군 중\n      가장 적합한 옵션을 함께 제안해 드립니다.\n    \u003c\/p\u003e\n  \u003c\/section\u003e\n\n\u003c\/div\u003e\n","products":[{"product_id":"spirochrome-sc001","title":"SiR-actin kit (SC001)","description":"\u003cp\u003eSiR-actin is a fluorogenic, cell permeable and highly specific probe for F-actin\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSize:\u003c\/strong\u003e 50 nmol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e room temperature\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Spirochrome","offers":[{"title":"Default Title","offer_id":48148925710560,"sku":"SC001","price":619.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/Spirochrome_fe575d99-d72c-49d8-a555-1075390c3805.png?v=1763716049"},{"product_id":"spirochrome-sc002","title":"SiR-tubulin kit (SC002)","description":"\u003cp\u003eSiR-tubulin is a fluorogenic, cell permeable and highly specific probe for microtubules\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSize:\u003c\/strong\u003e 50 nmol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e room temperature\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Spirochrome","offers":[{"title":"Default Title","offer_id":48148925743328,"sku":"SC002","price":619.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/Spirochrome_21b5c08b-047f-47d2-aa1b-d90020b00956.png?v=1763716050"},{"product_id":"spirochrome-sc003-1mg","title":"SiR-NHS ester (SC003-1mg)","description":"\u003cp\u003eSiR-NHS ester is the active ester form of SiR. 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Its optimized structure allows quick labeling of peroxisomes in live cells and tissues with high specificity and low background. Peroxi_SPY555 stains peroxisomes in live cells\nwithout the need for genetic manipulation or overexpression of fluorescent proteins. 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