{"product_id":"abbkine-prp1122-5g","title":"Human RSPO1\/R-spondin 1 Protein, His-SUMO tag (Animal-Free)","description":"\u003cp\u003e\u003cstrong\u003ePrimary Product Type:\u003c\/strong\u003e Cytokines and proteins\u003c\/p\u003e\u003cp\u003eR-spondin 1 (RSPO1, Roof plate-specific Spondin 1) is a cysteine-rich secreted glycoprotein that belongs to the R-Spondin family. Structurally, R-spondin 1 harbors an N-terminal signal peptide, two cysteine-rich furin-like (FU1-FU2) domains, a thrombospondin (TSP) domain, and a basic amino acid-rich (BR) C-terminal domain. R-spondin 1 acts as a ligand for the leucine-rich repeat-containing G-protein coupled receptor (LGR) family (LGR4\/5\/6), subsequent clearing negative regulators ZNRF3\/RNF43 from the membrane, leading to the availability of Wnt receptor and activating Wnt\/β-catenin signaling. The signal cascade is essential for regulating stem cell proliferation, embryonic development, and tissue homeostasis.\u003c\/p\u003e","brand":"Abbkine","offers":[{"title":"5 μg","offer_id":48527898837216,"sku":"PRP1122-5g","price":69.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/abbkine-logo-1_92e9dc7c-b582-4a21-a46e-16a7fe24c1d2.png?v=1768016729","url":"https:\/\/rndmate.com\/products\/abbkine-prp1122-5g","provider":"알앤디메이트","version":"1.0","type":"link"}