{"product_id":"active-protein-kinase-cgmp-dependent-type-ii-prkg2-aph313hu01","title":"Active Protein Kinase, cGMP Dependent Type II (PRKG2)","description":"\u003cp\u003eProduct No.\u003c\/p\u003e\n\u003cp\u003eAPH313Hu01\u003c\/p\u003e\n\u003cp\u003eOrganism Species\u003c\/p\u003e\n\u003cp\u003eHomo sapiens (Human).\u003c\/p\u003e\n\u003cp\u003eBuffer Formulation\u003c\/p\u003e\n\u003cp\u003e20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.\u003c\/p\u003e\n\u003cp\u003eTraits\u003c\/p\u003e\n\u003cp\u003eFreeze-dried powder\u003c\/p\u003e\n\u003cp\u003ePurity\u003c\/p\u003e\n\u003cp\u003e\u0026gt; 90%\u003c\/p\u003e\n\u003cp\u003eIsoelectric Point\u003c\/p\u003e\n\u003cp\u003e8.9\u003c\/p\u003e\n\u003cp\u003eApplications\u003c\/p\u003e\n\u003cp\u003eCell culture; Activity Assays.\u003c\/p\u003e\n\u003cp\u003eUOM\u003c\/p\u003e\n\u003cp\u003e10µg 50µg 200µg 1mg 5mg\u003c\/p\u003e\n\u003cdiv class=\"product\"\u003e\n\u003cdiv class=\"product_left\"\u003e\n\u003ch3\u003e\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product_relation\"\u003e\n\u003cbr\u003e\n\u003cdiv class=\"product\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product_left\" data-mce-fragment=\"1\"\u003e\n\u003ch3 data-mce-fragment=\"1\"\u003eACTIVITY TEST\u003c\/h3\u003e\n\u003cdiv data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003c\/p\u003e\n\u003cdiv class=\"product_image\" data-mce-fragment=\"1\"\u003e\n\u003cimg src=\"https:\/\/www.cloud-clone.com\/upload\/product\/pictures\/APH313Hu01-201805111146006384.jpg\" data-mce-fragment=\"1\" data-mce-src=\"https:\/\/www.cloud-clone.com\/upload\/product\/pictures\/APH313Hu01-201805111146006384.jpg\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eFigure. The binding activity of PRKG2 with HSP90aA1.\u003cbr data-mce-fragment=\"1\"\u003eProtein Kinase, cGMP Dependent Type II (PRKG2) belong to cGMP-dependent protein kinase or Protein Kinase G (PKG) which is a serine\/threonine-specific protein kinase that is activated by cGMP. Two PKG genes, coding for PKG type I (PKG-I) and type II (PKG-II), have been identified in mammals. The PKG-I and PKG-II are homodimers of two identical subunits (~75kDa and ~85kDa, respectively) and share common structural features. PKG phosphorylates a number of biologically important targets and is implicated in the regulation of smooth muscle relaxation, platelet function, sperm metabolism, cell division, and nucleic acid synthesis. Besides, Heat Shock Protein 90kDa Alpha A1 (HSP90aA1) has been identified as an interactor of PRKG2, thus a binding ELISA assay was conducted to detect the interaction of recombinant human PRKG2 and recombinant human HSP90aA1. Briefly, PRKG2 were diluted serially in PBS, with 0.01% BSA (pH 7.4). Duplicate samples of 100µL were then transferred to HSP90aA1-coated microtiter wells and incubated for 2h at 37℃. Wells were washed with PBST and incubated for 1h with anti-PRKG2 pAb, then aspirated and washed 3 times. After incubation with HRP labelled secondary antibody, wells were aspirated and washed 3 times. With the addition of substrate solution, wells were incubated 15-25 minutes at 37℃. Finally, add 50µL stop solution to the wells and read at 450nm immediately. The binding activity of PRKG2 and HSP90aA1 was shown in Figure 1, and this effect was in a dose dependent manner.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3 data-mce-fragment=\"1\"\u003eUSAGE\u003c\/h3\u003e\n\u003cdiv data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eReconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg\/mL. Do not vortex.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3 data-mce-fragment=\"1\"\u003eSTORAGE\u003c\/h3\u003e\n\u003cdiv data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eAvoid repeated freeze\/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3 data-mce-fragment=\"1\"\u003eSTABILITY\u003c\/h3\u003e\n\u003cdiv data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThe thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product_reference\" data-mce-fragment=\"1\"\u003e\n\u003ctable data-mce-fragment=\"1\"\u003e\n\u003ctbody data-mce-fragment=\"1\"\u003e\n\u003ctr class=\"first_tr\" data-mce-fragment=\"1\"\u003e\n\u003ctd class=\"td_1\" data-mce-fragment=\"1\"\u003eMagazine\u003c\/td\u003e\n\u003ctd data-mce-fragment=\"1\"\u003eCitations\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\"\u003e\n\u003ctd data-mce-fragment=\"1\"\u003ePLoS One\u003c\/td\u003e\n\u003ctd data-mce-fragment=\"1\"\u003eEnhanced heart failure, mortality and renin activation in female mice with experimental dilated cardiomyopathy\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29240788\" rel=\"nofollow\" data-mce-fragment=\"1\" data-mce-href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29240788\" target=\"_blank\"\u003epubmed:29240788\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product_relation\" data-mce-fragment=\"1\"\u003e\n\u003ctable data-mce-fragment=\"1\"\u003e\n\u003ctbody data-mce-fragment=\"1\"\u003e\n\u003ctr class=\"first_tr\" data-mce-fragment=\"1\"\u003e\n\u003ctd class=\"td_1\" data-mce-fragment=\"1\"\u003eCatalog No.\u003c\/td\u003e\n\u003ctd class=\"td_2\" data-mce-fragment=\"1\"\u003eRelated products for research use of Homo sapiens (Human) Organism species\u003c\/td\u003e\n\u003ctd class=\"td_3\" data-mce-fragment=\"1\"\u003eApplications (RESEARCH USE ONLY!)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\"\u003e\n\u003ctd data-mce-fragment=\"1\"\u003eAPH313Hu01\u003c\/td\u003e\n\u003ctd data-mce-fragment=\"1\"\u003e\u003ca href=\"https:\/\/www.cloud-clone.com\/products\/APH313Hu01.html\" data-mce-fragment=\"1\" data-mce-href=\"https:\/\/www.cloud-clone.com\/products\/APH313Hu01.html\"\u003eActive Protein Kinase, cGMP Dependent Type II (PRKG2)\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd data-mce-fragment=\"1\"\u003eCell culture; Activity Assays.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\"\u003e\n\u003ctd data-mce-fragment=\"1\"\u003eRPH313Hu01\u003c\/td\u003e\n\u003ctd data-mce-fragment=\"1\"\u003e\u003ca href=\"https:\/\/www.cloud-clone.com\/products\/RPH313Hu01.html\" data-mce-fragment=\"1\" data-mce-href=\"https:\/\/www.cloud-clone.com\/products\/RPH313Hu01.html\"\u003eRecombinant Protein Kinase, cGMP Dependent Type II (PRKG2)\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd data-mce-fragment=\"1\"\u003ePositive Control; Immunogen; SDS-PAGE; WB.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\"\u003e\n\u003ctd data-mce-fragment=\"1\"\u003ePAH313Hu01\u003c\/td\u003e\n\u003ctd data-mce-fragment=\"1\"\u003e\u003ca href=\"https:\/\/www.cloud-clone.com\/products\/PAH313Hu01.html\" data-mce-fragment=\"1\" data-mce-href=\"https:\/\/www.cloud-clone.com\/products\/PAH313Hu01.html\"\u003ePolyclonal Antibody to Protein Kinase, cGMP Dependent Type II (PRKG2)\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd data-mce-fragment=\"1\"\u003eWB; IHC; ICC; IP.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\"\u003e\n\u003ctd data-mce-fragment=\"1\"\u003eMAH313Hu21\u003c\/td\u003e\n\u003ctd data-mce-fragment=\"1\"\u003e\u003ca href=\"https:\/\/www.cloud-clone.com\/products\/MAH313Hu21.html\" data-mce-fragment=\"1\" data-mce-href=\"https:\/\/www.cloud-clone.com\/products\/MAH313Hu21.html\"\u003eMonoclonal Antibody to Protein Kinase, cGMP Dependent Type II (PRKG2)\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd data-mce-fragment=\"1\"\u003eWB; IHC; ICC; IP.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\"\u003e\n\u003ctd data-mce-fragment=\"1\"\u003eSEH313Hu\u003c\/td\u003e\n\u003ctd data-mce-fragment=\"1\"\u003e\u003ca href=\"https:\/\/www.cloud-clone.com\/products\/SEH313Hu.html\" data-mce-fragment=\"1\" data-mce-href=\"https:\/\/www.cloud-clone.com\/products\/SEH313Hu.html\"\u003eELISA Kit for Protein Kinase, cGMP Dependent Type II (PRKG2)\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd data-mce-fragment=\"1\"\u003eEnzyme-linked immunosorbent assay for Antigen Detection.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\"\u003e\n\u003ctd data-mce-fragment=\"1\"\u003eLMH313Hu\u003c\/td\u003e\n\u003ctd data-mce-fragment=\"1\"\u003e\u003ca href=\"https:\/\/www.cloud-clone.com\/products\/LMH313Hu.html\" data-mce-fragment=\"1\" data-mce-href=\"https:\/\/www.cloud-clone.com\/products\/LMH313Hu.html\"\u003eMagnetic Luminex Assay Kit for Protein Kinase, cGMP Dependent Type II (PRKG2) ,etc.\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd data-mce-fragment=\"1\"\u003eMagnetic Luminex Assay for Antigen Detection.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"more_info\" data-mce-fragment=\"1\"\u003e\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Cloud-clone","offers":[{"title":"50ug \/ \u003e 90% \/ Homo sapiens (Human)","offer_id":41485919224032,"sku":"APH313Hu01","price":900.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/NP_ef89b18b-0480-4fc2-9957-347c19bee9ed.jpg?v=1633608841","url":"https:\/\/rndmate.com\/products\/active-protein-kinase-cgmp-dependent-type-ii-prkg2-aph313hu01","provider":"알앤디메이트","version":"1.0","type":"link"}