anti- Cytokeratin 18 antibody

Our Anti-Cytokeratin 18 Antibody, available in a 100µg size, is a valuable tool for researchers studying cytokeratin 18, a type I cytokeratin protein that is expressed in various epithelial tissues, including the liver, gastrointestinal tract, and pancreas.

Accurate detection and quantification of cytokeratin 18 are essential for understanding its role in maintaining the structural integrity of epithelial cells and its potential implications in diseases such as hepatocellular carcinoma. This antibody has undergone rigorous validation for specificity and sensitivity, ensuring reliable results in applications such as immunohistochemistry and immunofluorescence.

With its compact size, this antibody offers versatility in experimental approaches, allowing you to explore cytokeratin 18 expression and localization in different tissues and cell types. Trust in the quality of our Anti-Cytokeratin 18 Antibody to advance your research and contribute to our understanding of cytokeratin 18's significance in epithelial biology.

Product Name

Cytokeratin 18 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Keratins are a large family of proteins that form the intermediate filament cytoskeleton of epithelial cells, which are classified into two major sequence types. Type I keratins are a group of acidic intermediate filament proteins, including K9–K23, and the hair keratins Ha1–Ha8. Type II keratins are the basic or neutral courterparts to the acidic type I keratins, including K1–K8, and the hair keratins, Hb1–Hb6. KRT18, also named as CYK18, PIG46 and K18, is the most commonly found members of the intermediate filament gene family. KRT18 is a type I keratin which is found primarily in non squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas.

IMMUNOGEN INFORMATION

Immunogen

keratin 18

Synonyms

CK 18, CYK18, Cytokeratin 18, K18, keratin 18, KRT18

Observed MW

48 kDa

APPLICATION

Tested Application

ELISA, WB, FC, IF, IHC

Recommended Dilution

WB: 1:5000-1:30000; IHC: 1:500-1:1000; IF: 1:100-1:300

UNIPROT INFORMATION

UniProt ID

P05783

IMAGES