{"product_id":"anti-foxp3-antibody-fnab03209","title":"anti- FOXP3 antibody","description":"\u003cp\u003eInvestigate the functions of Forkhead Box P3 (FOXP3) in immunology, autoimmunity, and regulatory T cell research with our Anti-FOXP3 Antibody, available in a 100µg vial. FOXP3 is a crucial transcription factor in these fields, with profound implications for immune system regulation. This highly specific antibody empowers researchers to explore FOXP3's functions, contributing to a deeper understanding of its impact on health and disease.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKey Features:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eExceptional Specificity:\u003c\/strong\u003e Our Anti-FOXP3 Antibody is rigorously tested to ensure it accurately targets FOXP3, minimizing the risk of cross-reactivity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVersatile Applications:\u003c\/strong\u003e Ideal for various experimental techniques, including immunohistochemistry, flow cytometry, and ChIP assays.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAmple Quantity:\u003c\/strong\u003e With 100µg, you have a generous supply for multiple experiments.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTop-Tier Quality:\u003c\/strong\u003e Manufactured to the highest industry standards, guaranteeing consistent and reproducible results.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdvance Your Research:\u003c\/strong\u003e Whether you're studying immunology, T cell regulation, or autoimmunity, our Anti-FOXP3 Antibody is your key to investigating FOXP3.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Name\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFOXP3 antibody\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSize\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e100µg\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eForm\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eliquid\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurification\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eImmunogen affinity purified\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e≥95% as determined by SDS-PAGE\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHost\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eRabbit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eClonality\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003epolyclonal\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIsotype\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIgG\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze \/ thaw cycles.)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBACKGROUND\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTranscriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells(Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2(IL2) and interferon-gamma(IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2(PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7(PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1(PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells(Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development(PubMed:18368049). Inhibits the transcriptional activator activity of RORA(PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4(By similarity).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIMMUNOGEN INFORMATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImmunogen\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eforkhead box P3\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAIID, DIETER, forkhead box P3, Forkhead box protein P3, FOXP3, IPEX, JM2, PIDX, Scurfin, XPID\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eObserved MW\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e50 kDa\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAPPLICATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTested Application\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eELISA, WB, IP\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRecommended Dilution\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWB: 1:500-1:2000; IP: 1:500-1:2000\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUNIPROT INFORMATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUniProt ID\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"http:\/\/www.uniprot.org\/uniprot\/Q9BZS1\"\u003eQ9BZS1\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIMAGES\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cfigure class=\"w-full md:w-2\/3 p-2 border relative\"\u003e\u003cimg class=\"mx-auto\" alt=\"\" src=\"https:\/\/www.fn-test.com\/content\/uploads\/product\/images\/antibody\/image3\/FNab03209.jpg\"\u003e\u003c\/figure\u003e\n\u003cdiv class=\"w-full md:pl-8 pt-4 md:pt-0 md:w-1\/3\"\u003eIP Result of anti-FOXP3 (IP:FNab03209, 3ug; Detection:FNab03209 1:1000) with HeLa cells lysate 1840ug.\u003c\/div\u003e\n\u003cfigure class=\"w-full md:w-2\/3 p-2 border relative\"\u003e\u003cimg class=\"mx-auto\" alt=\"\" src=\"https:\/\/www.fn-test.com\/content\/uploads\/product\/images\/antibody\/image4\/FNab03209.jpg\"\u003e\u003c\/figure\u003e\n\u003cdiv class=\"w-full md:pl-8 pt-4 md:pt-0 md:w-1\/3\"\u003eHeLa cells were subjected to SDS PAGE followed by western blot with FNab03209(FOXP3 antibody) at dilution of 1:2000\u003c\/div\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"FineTest","offers":[{"title":"100µg","offer_id":42429841047776,"sku":"FNab03209","price":290.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/fine_test_logo_428a5ead-e248-4f2e-aae7-660ecda8f4b9.jpg?v=1645521194","url":"https:\/\/rndmate.com\/products\/anti-foxp3-antibody-fnab03209","provider":"알앤디메이트","version":"1.0","type":"link"}