{"product_id":"anti-padi4-antibody-fnab06105","title":"anti- PADI4 antibody","description":"\u003cp\u003e\u003cstrong\u003ePRODUCT INFORMATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Name\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePADI4 antibody\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSize\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e100µg\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eForm\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eliquid\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurification\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eImmunogen affinity purified\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e≥95% as determined by SDS-PAGE\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHost\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eRabbit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eClonality\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003epolyclonal\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIsotype\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIgG\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze \/ thaw cycles.)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBACKGROUND\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCatalyzes the citrullination\/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54'(to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and\/or 'Arg-26'(to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3'(to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1(H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2\/PRMT1 and represses transcription. Citrullinates EP300\/P300 at 'Arg-2142', which favors its interaction with NCOA2\/GRIP1.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIMMUNOGEN INFORMATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImmunogen\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003epeptidyl arginine deiminase, type IV\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePAD4, PADI5, PDI5\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eObserved MW\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e74 kDa\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAPPLICATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTested Application\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eELISA, WB, IHC, IF\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRecommended Dilution\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWB: 1:500-1:2000; IHC: 1:100-1:500; IF: 1:10-1:100\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUNIPROT INFORMATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUniProt ID\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"http:\/\/www.uniprot.org\/uniprot\/Q9UM07\"\u003eQ9UM07\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e \u003cimg src=\"https:\/\/www.fn-test.com\/content\/uploads\/product\/images\/antibody\/image1\/FNab06105.jpg\" data-mce-fragment=\"1\" data-mce-src=\"https:\/\/www.fn-test.com\/content\/uploads\/product\/images\/antibody\/image1\/FNab06105.jpg\"\u003e\u003c\/p\u003e\n\u003cdiv class=\"w-full md:pl-8 pt-4 md:pt-0 md:w-1\/3\"\u003eImmunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab06105(PADI4 Antibody) at dilution of 1:200\u003c\/div\u003e\n\u003cfigure class=\"w-full md:w-2\/3 p-2 border relative\"\u003e\u003c\/figure\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"FineTest","offers":[{"title":"100µg","offer_id":42429740908768,"sku":"FNab06105","price":290.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/fine_test_logo_59d2d7b6-0c37-4ecf-b191-6caed5cb89de.jpg?v=1645518041","url":"https:\/\/rndmate.com\/products\/anti-padi4-antibody-fnab06105","provider":"알앤디메이트","version":"1.0","type":"link"}