{"product_id":"belzutifan","title":"Belzutifan","description":"\u003cp\u003e\u003cstrong\u003e\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003eBelzutifan, also known as PT2977 and MK-6482, is HIF-2alpha inhibitor. PT2977 binds to and blocks the function of HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate hypoxic signaling. This inhibits cell growth and survival of HIF-2alpha-expressing tumor cells. HIF-2alpha, the alpha subunit for the heterodimeric transcription factor HIF-2, is overexpressed in many cancers and promotes tumorigenesis. Belzutifan was approved in 2021 for treatment of von Hippel-Lindau disease under certain conditions\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSynonym:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003eMK-6482; MK 6482; MK6482; PT2977; PT-2977; PT 2977; Belzutifan\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIUPAC\/Chemical Name:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003e3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInChi Key:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003eLOMMPXLFBTZENJ-ZACQAIPSSA-N\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInChi Code:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003eInChI=1S\/C17H12F3NO4S\/c1-26(23,24)12-3-2-11(13-14(12)17(22)16(20)15(13)19)25-10-5-8(7-21)4-9(18)6-10\/h2-6,15-17,22H,1H3\/t15-,16-,17+\/m1\/s1\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSMILES Code:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003eN#CC1=CC(F)=CC(OC2=CC=C(S(=O)(C)=O)C3=C2[C@@H](F)[C@@H](F)[C@H]3O)=C1\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAppearance:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003eSolid powder\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003e\u0026gt;98% (or refer to the Certificate of Analysis)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eShipping Condition:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003eShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage Condition:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003eDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSolubility:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003eSoluble in DMSO\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eShelf Life:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003e\u0026gt;3 years if stored properly\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDrug Formulation:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003eThis drug may be formulated in DMSO\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStock Solution Storage:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003e0 - 4 C for short term (days to weeks), or -20 C for long term (months).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHS Tariff Code:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003e2934.99.9001\u003c\/p\u003e","brand":"medkoo biosciencs","offers":[{"title":"Default Title","offer_id":44925467197664,"sku":"207004","price":0.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/Belzutifan.jpg?v=1709946761","url":"https:\/\/rndmate.com\/products\/belzutifan","provider":"알앤디메이트","version":"1.0","type":"link"}