{"product_id":"caspase-14-polyclonal-antibody-bt-lab","title":"Caspase-14 Polyclonal Antibody","description":"\u003cp\u003eCASP14 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 14 has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of caspase 14 may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.\u003c\/p\u003e\n\u003cp\u003eThe Caspase-14 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Caspase-14 protein in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional performance and reliability.\u003cbr\u003e\u003cbr\u003eCaspase-14 is a crucial member of the caspase family, playing a significant role in the regulation of apoptosis and keratinocyte differentiation. It is predominantly expressed in the epidermis, where it participates in the maintenance of skin homeostasis and barrier function. The Caspase-14 Polyclonal Antibody recognizes the full-length Caspase-14 protein as well as its cleaved fragments, enabling comprehensive analysis of its expression and activation status.\u003cbr\u003e\u003cbr\u003eThis antibody exhibits exceptional specificity, exhibiting minimal cross-reactivity with other caspase family members. It has been rigorously validated through various experimental approaches, including Western blotting, immunohistochemistry, and immunofluorescence, ensuring accurate and reproducible results. The high sensitivity of this antibody allows for the detection of low-abundance Caspase-14 protein, even in limited sample quantities.\u003cbr\u003e\u003cbr\u003eThe Caspase-14 Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without compromising its quality. The antibody has been optimized for use in diverse applications, including research studies, drug development, and diagnostic assays.\u003cbr\u003e\u003cbr\u003eIn summary, the Caspase-14 Polyclonal Antibody is a reliable and efficient tool for investigating the role of Caspase-14 in various biological processes. Its exceptional specificity, sensitivity, and versatility make it an invaluable asset for researchers and scientists working in the field of apoptosis, skin biology, and related disciplines.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":42357769666784,"sku":"BT-AP01197","price":275.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/BT_Lab_d690e6b1-c137-437d-8761-6c99401cd6d2.png?v=1644579568","url":"https:\/\/rndmate.com\/products\/caspase-14-polyclonal-antibody-bt-lab","provider":"알앤디메이트","version":"1.0","type":"link"}