{"product_id":"cleaved-notch-2-v1697-polyclonal-antibody-bt-lab","title":"Cleaved-Notch 2 (V1697) Polyclonal Antibody","description":"\u003cp\u003eNOTCH2 encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. The notch 2 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. The notch 2 functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\u003cp\u003eThe Cleaved-Caspase-6 p18 (D179) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of cleaved caspase-6 p18 protein in various biological samples. This antibody has been meticulously developed using advanced immunization techniques and exhibits exceptional affinity and selectivity towards the target protein.\u003cbr\u003e\u003cbr\u003eCaspase-6 is a crucial enzyme involved in the execution phase of apoptosis, playing a pivotal role in cellular homeostasis and tissue development. The cleaved form of caspase-6, known as p18, is a reliable marker for the activation of caspase-6 and is widely used in research studies to investigate apoptotic pathways and cellular death mechanisms.\u003cbr\u003e\u003cbr\u003eThe Cleaved-Caspase-6 p18 (D179) Polyclonal Antibody demonstrates outstanding performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other caspase family members, ensuring accurate and specific detection of cleaved caspase-6 p18.\u003cbr\u003e\u003cbr\u003eThis antibody is produced using high-quality materials and undergoes rigorous quality control procedures to ensure batch-to-batch consistency and reproducibility. It is supplied as a liquid formulation, ready for immediate use, and is compatible with a wide range of experimental conditions and protocols.\u003cbr\u003e\u003cbr\u003eResearchers and scientists can rely on the Cleaved-Caspase-6 p18 (D179) Polyclonal Antibody to provide reliable and precise results in their studies related to apoptosis, cellular death, and caspase-6 activation. Its exceptional sensitivity and specificity make it an indispensable tool for elucidating the intricate mechanisms underlying these processes.\u003cbr\u003e\u003cbr\u003ePlease note that this product is for research use only and is not intended for diagnostic or therapeutic purposes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":42357822750944,"sku":"BT-AP01956","price":275.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/BT_Lab_69c59c09-81d5-4bb9-b458-2b58b4d9ec3e.png?v=1644574675","url":"https:\/\/rndmate.com\/products\/cleaved-notch-2-v1697-polyclonal-antibody-bt-lab","provider":"알앤디메이트","version":"1.0","type":"link"}