{"product_id":"col4a4-polyclonal-antibody-bt-lab","title":"COL4A4 Polyclonal Antibody","description":"\u003cp\u003eCOL4A4 encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the type IV collagen gene family, COL4A4 is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease). Two transcripts, differing only in their transcription start sites, have been identified for this gene and, as is common for collagen genes, multiple polyadenylation sites are found in the 3' UTR.\u003c\/p\u003e\n\u003cp\u003eThe COL4A5 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of COL4A5 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human COL4A5 protein. The antibody has been purified using protein A affinity chromatography and is suitable for use in various applications, including Western blotting, immunohistochemistry, and ELISA.\u003cbr\u003e\u003cbr\u003eThe COL4A5 Polyclonal Antibody is a valuable tool for researchers studying the role of COL4A5 in various physiological and pathological processes. COL4A5 is a type IV collagen protein that is primarily expressed in the basement membrane of the kidney glomerulus and the inner ear. Mutations in the COL4A5 gene are associated with X-linked Alport syndrome, a genetic disorder characterized by progressive kidney disease, hearing loss, and eye abnormalities.\u003cbr\u003e\u003cbr\u003eThe high specificity and sensitivity of the COL4A5 Polyclonal Antibody make it an ideal reagent for the detection of COL4A5 protein in various biological samples. The antibody has been validated for use in human, mouse, and rat samples and has been shown to detect endogenous levels of COL4A5 protein in kidney and inner ear tissues. The antibody is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.\u003cbr\u003e\u003cbr\u003eIn summary, the COL4A5 Polyclonal Antibody is a reliable and effective tool for the detection of COL4A5 protein in various biological samples. Its high specificity and sensitivity make it an ideal reagent for researchers studying the role of COL4A5 in various physiological and pathological processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":42357831303392,"sku":"BT-AP02085","price":275.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/BT_Lab_c9f49ca8-0828-4c3d-9f6f-cfbc9f1d03e6.png?v=1644578797","url":"https:\/\/rndmate.com\/products\/col4a4-polyclonal-antibody-bt-lab","provider":"알앤디메이트","version":"1.0","type":"link"}