{"product_id":"es10250","title":"3BP1 rabbit pAb","description":"\u003cstrong\u003eApplications:\u003c\/strong\u003e WB;ELISA\u003cbr\u003e\u003cstrong\u003eReactivity:\u003c\/strong\u003e Human;Mouse\u003cbr\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e Rabbit\u003cbr\u003e\u003cstrong\u003eDilution:\u003c\/strong\u003e WB 1:500-2000 ELISA 1:5000-20000\u003cbr\u003e\u003cstrong\u003eImmunogen:\u003c\/strong\u003e Synthesized peptide derived from human protein . at AA range: 170-250\u003cbr\u003e\u003cstrong\u003eStorage_stability:\u003c\/strong\u003e -20°C\/1 year\u003cbr\u003e\u003cstrong\u003eClonality:\u003c\/strong\u003e Polyclonal\u003cbr\u003e\u003cstrong\u003eIsotype:\u003c\/strong\u003e IgG\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1 mg\/ml\u003cbr\u003e\u003cstrong\u003eObserved_band(KD):\u003c\/strong\u003e 77kD\u003cbr\u003e\u003cstrong\u003eHuman_gene_id:\u003c\/strong\u003e 23616\u003cbr\u003e\u003cstrong\u003eHuman_swiss_prot_no:\u003c\/strong\u003e Q9Y3L3\u003cbr\u003e\u003cstrong\u003eSubcellular_location:\u003c\/strong\u003e Cell projection . Cell junction, tight junction . Cell junction, adherens junction . Cell projection, phagocytic cup . Nucleus . Cytoplasm, cytosol . Localizes at the leading edge of migrating cells (PubMed:21658605, PubMed:24841563). Accumulation at forming phagocytic cups is PI3 kinase\/PI3K-dependent and is specific for sites of large particles engagement and their phosphatidylinositol 3,4,5-triphosphate membrane content (PubMed:26465210). .\u003cbr\u003e\u003cstrong\u003eBackground:\u003c\/strong\u003e function:Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac.,sequence caution:Translated as Cys.,similarity:Contains 1 BAR domain.,similarity:Contains 1 Rho-GAP domain.,","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":47541495398624,"sku":"ES10250","price":250.0,"currency_code":"KRW","in_stock":true}],"url":"https:\/\/rndmate.com\/products\/es10250","provider":"알앤디메이트","version":"1.0","type":"link"}