{"product_id":"f40199-0-4ml","title":"SET07 Antibody","description":"\u003cp\u003eSET07 is a protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53\/TP53 at 'Lys-382', leading to repress p53\/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. [UniProt]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml \/ Mouse","offer_id":46768953524448,"sku":"F40199-0.4ML","price":429.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_1421ad06-98b6-4745-b943-09252bbed309.jpg?v=1734509352","url":"https:\/\/rndmate.com\/products\/f40199-0-4ml","provider":"알앤디메이트","version":"1.0","type":"link"}