{"product_id":"f53948-0-2ml","title":"JNK\/SAPK Antibody (pThr183\/Tyr185)","description":"\u003cp\u003eSerine\/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase\/c-Jun N-terminal kinase (SAP\/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4\/MKK4 and MAP2K7\/MKK7 phosphorylate and activate MAPK9\/JNK2. In turn, MAPK9\/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7\/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin\/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL\/BMAL1 heterodimer and plays a role in the regulation of the circadian clock.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.2 ml \/ Rabbit","offer_id":46768632365280,"sku":"F53948-0.2ML","price":429.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_422c0620-f0a4-4dad-b24c-69ebc77e4ffb.jpg?v=1734494190","url":"https:\/\/rndmate.com\/products\/f53948-0-2ml","provider":"알앤디메이트","version":"1.0","type":"link"}