{"product_id":"gas6-protein-human-hek293-fc","title":"GAS6 Protein, Human (HEK293, Fc)","description":"\u003ctable id=\"detailsTblCytokines\" class=\"details_info_tbl\" data-mce-fragment=\"1\"\u003e\n\u003ctbody id=\"descriptionTbl\" data-mce-fragment=\"1\"\u003e\n\u003ctr data-mce-fragment=\"1\"\u003e\n\u003cth style=\"width: 79.2125px;\" class=\"details_info_th\" data-mce-style=\"width: 79.2125px;\" data-mce-fragment=\"1\"\u003eDescription\u003c\/th\u003e\n\u003ctd style=\"width: 455.188px;\" class=\"details_info_td\" data-mce-style=\"width: 455.188px;\" data-mce-fragment=\"1\"\u003e\n\u003cdiv data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eGAS6 Protein, a ligand for AXL,\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.medchemexpress.com\/proteins\/tyro3.html\" target=\"_blank\" data-mce-href=\"https:\/\/www.medchemexpress.com\/proteins\/tyro3.html\" data-mce-fragment=\"1\"\u003eTYRO3\u003c\/a\u003e, and MER receptors, influences diverse cellular processes. GAS6\/AXL signaling promotes endothelial cell survival, aids cytokine signaling in natural killer cell development, supports hepatic regeneration, influences gonadotropin-releasing hormone neuron survival and migration, regulates platelet activation, and modulates thrombotic responses. In microbial infections, GAS6 acts as a bridge between virus envelope phosphatidylserine and\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.medchemexpress.com\/Targets\/TAM%20Receptor.html\" target=\"_blank\" data-mce-href=\"https:\/\/www.medchemexpress.com\/Targets\/TAM%20Receptor.html\" data-mce-fragment=\"1\"\u003eTAM receptor\u003c\/a\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003etyrosine kinase Axl, facilitating viral entry in apoptotic mimicry. This multifunctional role extends to diverse viruses, such as Dengue, Vaccinia, ebolavirus, and marburgvirus. GAS6 Protein, Human (HEK293, Fc) is the recombinant human-derived GAS6 protein, expressed by\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003ci data-mce-fragment=\"1\"\u003eHEK293\u003c\/i\u003e, with C-hFc labeled tag. The total length of GAS6 Protein, Human (HEK293, Fc) is 648 a.a., with molecular weight of 110-120 kDa.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-mce-fragment=\"1\"\u003e\n\u003cth style=\"width: 79.2125px;\" class=\"details_info_th\" data-mce-style=\"width: 79.2125px;\" data-mce-fragment=\"1\"\u003eBackground\u003c\/th\u003e\n\u003ctd style=\"width: 455.188px;\" class=\"details_info_td\" data-mce-style=\"width: 455.188px;\" data-mce-fragment=\"1\"\u003e\n\u003cdiv data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eGAS6, a ligand for tyrosine-protein kinase receptors AXL,\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.medchemexpress.com\/proteins\/tyro3.html\" target=\"_blank\" data-mce-href=\"https:\/\/www.medchemexpress.com\/proteins\/tyro3.html\" data-mce-fragment=\"1\"\u003eTYRO3\u003c\/a\u003e, and MER, is implicated in diverse cellular processes including cell growth, survival, adhesion, and migration. GAS6\/AXL signaling contributes to endothelial cell survival under acidic conditions by preventing\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.medchemexpress.com\/Targets\/Apoptosis.html\" target=\"_blank\" data-mce-href=\"https:\/\/www.medchemexpress.com\/Targets\/Apoptosis.html\" data-mce-fragment=\"1\"\u003eapoptosis\u003c\/a\u003e, facilitates optimal cytokine signaling during human natural killer cell development, plays a role in hepatic regeneration, influences gonadotropin-releasing hormone neuron survival and migration, regulates platelet activation, and modulates thrombotic responses. Additionally, in microbial infections, GAS6 can act as a bridge between virus envelope phosphatidylserine and the\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.medchemexpress.com\/Targets\/TAM%20Receptor.html\" target=\"_blank\" data-mce-href=\"https:\/\/www.medchemexpress.com\/Targets\/TAM%20Receptor.html\" data-mce-fragment=\"1\"\u003eTAM receptor\u003c\/a\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003etyrosine kinase Axl, facilitating viral entry through apoptotic mimicry. This unique function extends to its involvement in the entry processes of diverse viruses, including Dengue, Vaccinia, ebolavirus, and marburgvirus, highlighting the multifaceted roles of GAS6 in cellular and infectious contexts.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable id=\"detailsTblCytokines\" class=\"details_info_tbl\"\u003e\n\u003ctbody id=\"technicalTbl\"\u003e\n\u003ctr\u003e\n\u003cth class=\"details_info_th\"\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd class=\"details_info_td\"\u003e\n\u003cdiv\u003e\n\u003cp id=\"molecularWeight\"\u003e110-120 kDa\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth class=\"details_info_th\"\u003ePurity\u003c\/th\u003e\n\u003ctd class=\"details_info_td\"\u003e\n\u003cdiv\u003e\n\u003cp\u003eGreater than 95% as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003ctbody id=\"propertiesTbl\"\u003e\n\u003ctr\u003e\n\u003cth class=\"details_info_th\"\u003eAppearance\u003c\/th\u003e\n\u003ctd class=\"details_info_td\"\u003e\n\u003cdiv\u003e\n\u003cp\u003eLyophilized powder.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth class=\"details_info_th\"\u003eFormulation\u003c\/th\u003e\n\u003ctd class=\"details_info_td\"\u003e\n\u003cdiv\u003e\n\u003cp\u003eLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth class=\"details_info_th\"\u003eEndotoxin Level\u003c\/th\u003e\n\u003ctd class=\"details_info_td\"\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u0026lt;1 EU\/μg, determined by LAL method.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth class=\"details_info_th\"\u003eReconstitution\u003c\/th\u003e\n\u003ctd class=\"details_info_td\"\u003e\n\u003cdiv\u003e\n\u003cp\u003eIt is not recommended to reconstitute to a concentration less than 100 μg\/mL in ddH\u003csub\u003e2\u003c\/sub\u003eO. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth class=\"details_info_th\"\u003eStorage \u0026amp; Stability\u003c\/th\u003e\n\u003ctd class=\"details_info_td\"\u003e\n\u003cdiv\u003e\n\u003cp\u003eStored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"MedChemExpress","offers":[{"title":"Default Title","offer_id":44598687924448,"sku":"HY-P70470","price":384.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/cytonkines-demo.jpg?v=1705020107","url":"https:\/\/rndmate.com\/products\/gas6-protein-human-hek293-fc","provider":"알앤디메이트","version":"1.0","type":"link"}