{"product_id":"hspa5-grp78-active-protein-human-protein","title":"HSPA5 \/ GRP78 (Active Protein) Human Protein","description":"\u003ctable class=\"table table-striped table-bordered attributes-table\"\u003e\n\u003ctbody\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003eSpecies\u003c\/td\u003e\n\u003ctd\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003eExpression Host\u003c\/td\u003e\n\u003ctd\u003eE. coli\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003eConcentration\u003c\/td\u003e\n\u003ctd\u003elot specific\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003ePurity\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;90% pure as determined by SDS-PAGE analysis\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003ePresentation\u003c\/td\u003e\n\u003ctd\u003ePurified\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003eBuffer\u003c\/td\u003e\n\u003ctd\u003ePresentation State: Purified\u003cbr\u003eState: Liquid purified protein\u003cbr\u003eBuffer System: 50 mM Tris\/HCl, pH 7.5, 150 mM NaCl and 10% Glycerol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003ePreparation\u003c\/td\u003e\n\u003ctd\u003eLiquid purified protein\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003eApplications\u003c\/td\u003e\n\u003ctd\u003e\n\u003cstrong\u003eWestern Blot Control.\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003eATPase activity.\u003cbr\u003e\u003c\/strong\u003eThis protein has ATPase activity at the time of manufacture of 2.3 µM Phosphate liberated\/hr\/µg protein in a 200 µl reaction at 37°C (pH 8) in the presence of 20 µl of 1mM ATP using Malachite Green Assay.\u003cbr\u003e\u003cstrong\u003eBinding Assay.\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003eELISA reference standard.\u003c\/strong\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003eProtein Description\u003c\/td\u003e\n\u003ctd\u003eRecombinant Human GRP78 Protein with ATPase activity, His-tagged.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003eStorage\u003c\/td\u003e\n\u003ctd\u003eUpon receipt, store undiluted (in aliquots) at -20°C.\u003cbr\u003eAvoid repeated freezing and thawing.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003eStability\u003c\/td\u003e\n\u003ctd\u003eShelf life: one year from despatch.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"2\"\u003e\n\u003ci class=\"fa fa-external-link fa-2x fa-fw\"\u003e\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"h5\"\u003eReference Data\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003eRefSeq\u003c\/td\u003e\n\u003ctd\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/nuccore\/NP_005338\" target=\"_blank\"\u003eNP_005338\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003eLocus ID\u003c\/td\u003e\n\u003ctd\u003e3309\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003eUniProt ID\u003c\/td\u003e\n\u003ctd\u003e\n\u003ca rel=\"noopener\" href=\"https:\/\/www.uniprot.org\/uniprot\/P11021\" target=\"_blank\"\u003eP11021\u003c\/a\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.uniprot.org\/uniprot\/V9HWB4\" target=\"_blank\"\u003eV9HWB4\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003eCytogenetics\u003c\/td\u003e\n\u003ctd\u003e9q33.3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003eSynonyms\u003c\/td\u003e\n\u003ctd\u003eBIP; GRP78; HEL-S-89n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003eSummary\u003c\/td\u003e\n\u003ctd\u003eThe protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020]\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003eProtein Families\u003c\/td\u003e\n\u003ctd\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.origene.com\/search?q=Druggable%20Genome\u0026amp;sub_category=Recombinant%20Proteins\u0026amp;families_filter=Druggable%20Genome\" target=\"_blank\"\u003eDruggable Genome\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"attribute\"\u003e\n\u003ctd\u003eProtein Pathways\u003c\/td\u003e\n\u003ctd\u003e\n\u003ca rel=\"noopener\" href=\"https:\/\/www.origene.com\/search?q=Antigen%20processing%20and%20presentation\u0026amp;sub_category=Recombinant%20Proteins\u0026amp;pathways_filter=Antigen%20processing%20and%20presentation\" target=\"_blank\"\u003eAntigen processing and presentation\u003c\/a\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.origene.com\/search?q=Prion%20diseases\u0026amp;sub_category=Recombinant%20Proteins\u0026amp;pathways_filter=Prion%20diseases\" target=\"_blank\"\u003ePrion diseases\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"ORIGENE","offers":[{"title":"Default Title","offer_id":44911794225376,"sku":"AR03021PU-L","price":0.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/ar03021pu-l-1.png?v=1709755255","url":"https:\/\/rndmate.com\/products\/hspa5-grp78-active-protein-human-protein","provider":"알앤디메이트","version":"1.0","type":"link"}