{"product_id":"lck-bp-1-phospho-tyr378-polyclonal-antibody-bt-lab","title":"Lck BP-1(Phospho Tyr378) Polyclonal Antibody","description":"\u003cp\u003edevelopmental stage:Expressed in early stage of myeloid and erythroid differentiation.,Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.,PTM:Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells.,Contains 1 SH3 domain.,Contains 4 cortactin repeats.,subunit:Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3.,tissue specificity:Expressed only in tissues and cells of hematopoietic origin.,\u003c\/p\u003e\n\u003cp\u003eThe Lck BP-1(Phospho Tyr378) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Lck protein phosphorylated at Tyr378. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity for the target protein.\u003cbr\u003e\u003cbr\u003eThe Lck BP-1(Phospho Tyr378) Polyclonal Antibody is suitable for various applications, including Western blotting, immunoprecipitation, and immunohistochemistry. It has been extensively validated and proven to provide reliable and reproducible results in these assays.\u003cbr\u003e\u003cbr\u003eThis antibody is manufactured using high-quality materials and undergoes rigorous quality control procedures to ensure batch-to-batch consistency and optimal performance. It is supplied as a liquid formulation, ready to use for immediate experimentation.\u003cbr\u003e\u003cbr\u003eThe Lck BP-1(Phospho Tyr378) Polyclonal Antibody offers researchers a valuable tool for studying the phosphorylation status of Lck protein at Tyr378. Its high specificity and sensitivity make it an ideal choice for investigating the role of Lck in various cellular processes and signaling pathways.\u003cbr\u003e\u003cbr\u003eOrder your Lck BP-1(Phospho Tyr378) Polyclonal Antibody today and unlock new insights into the function and regulation of Lck protein.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":42359121477856,"sku":"BT-AP10863","price":275.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/BT_Lab_2a151bc4-0d52-46eb-9826-b8760e1ca1af.png?v=1644578293","url":"https:\/\/rndmate.com\/products\/lck-bp-1-phospho-tyr378-polyclonal-antibody-bt-lab","provider":"알앤디메이트","version":"1.0","type":"link"}