{"product_id":"m-san-hq-25-25ku-1-ml","title":"M-SAN HQ 25-25kU","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003cdiv id=\"overview\" class=\"product_content\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product_rte w-richtext\" data-mce-fragment=\"1\"\u003e\n\u003ch3 data-mce-fragment=\"1\"\u003eM-SAN HQ  - Peak performance where it matters most at physiological conditions\u003c\/h3\u003e\n\u003cp data-mce-fragment=\"1\"\u003eMedium-Salt Active Nuclease High Quality (M-SAN HQ) is a Bioprocessing Grade nuclease developed for removal of both single and double-stranded DNA and RNA at the physiological salt conditions most often used in bioprocessing and biomanufacturing workflows. M-SAN HQ allows you to directly replace Benzonase without changing your workflow.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThis novel, nonspecific endonuclease is active over a broad pH range and displays optimum activity at salt concentrations between 125 – 250 mM. Due to its excellent performance at physiological conditions, M-SAN HQ can be used directly in the cell medium or the harvested supernatant without buffer adjustments. This makes M-SAN HQ ideal for the manufacturing of fragile vectors such as lentiviruses and retroviruses.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eM-SAN HQ can be directly used in medium without buffer adjustments\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003c\/strong\u003eThe high activity of M-SAN HQ at standard cell medium conditions leads to improved DNA clearance compared to other commonly used nucleases. In the data (see Figure 6), an over 2-fold reduction in residual DNA was achieved. \u003c\/p\u003e\n\u003ch3 data-mce-fragment=\"1\"\u003eKey Benefits\u003c\/h3\u003e\n\u003cul role=\"list\" data-mce-fragment=\"1\"\u003e\n\u003cli data-mce-fragment=\"1\"\u003e\n\u003cstrong data-mce-fragment=\"1\"\u003eCompatibility:\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003c\/strong\u003eIdeal for working with both fragile and robust viral vectors and proteins in a variety of cell media\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003e\n\u003cstrong data-mce-fragment=\"1\"\u003eOptimum activity\u003c\/strong\u003e: Optimization for cell media salinity allows both shorter DNA fragments and reduced incubation times.\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003e\n\u003cstrong data-mce-fragment=\"1\"\u003eProcess Efficiency\u003c\/strong\u003e: Smaller DNA fragments simplifies DSP workflows.\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003e\n\u003cstrong data-mce-fragment=\"1\"\u003eCost-Effectiveness\u003c\/strong\u003e: Reduced need for additional reagents and steps can lower production costs\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003e\n\u003cstrong data-mce-fragment=\"1\"\u003eQuality:\u003c\/strong\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003eMaintains the integrity of sensitive or labile biological molecules, ensuring a higher quality end product\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003e\n\u003cstrong data-mce-fragment=\"1\"\u003eTime-Saving:\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003c\/strong\u003eStreamlined protocol speeds up the manufacturing process\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003e\n\u003cstrong data-mce-fragment=\"1\"\u003eFlexibility:\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003c\/strong\u003eCan be used directly in a variety of media without the need for customization\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 data-mce-fragment=\"1\"\u003eKey Features \u003c\/h3\u003e\n\u003cul role=\"list\" data-mce-fragment=\"1\"\u003e\n\u003cli data-mce-fragment=\"1\"\u003eHigh purity (≥ 99%)\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eNo protease detected\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eEndotoxin-tested\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eAnimal origin-free production\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eSupplied with extended product documentation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 data-mce-fragment=\"1\"\u003eAdapted to use in medium without salinity adjustments \u003c\/h3\u003e\n\u003cp data-mce-fragment=\"1\"\u003eOptimal activity at physiological salinity and pH makes it ideal for DNA removal from mammalian cell media. (see Figures)\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThe high activity of M-SAN HQ at the physiological salinity and pH found in standard cell medium conditions leads to improved DNA clearance compared to commonly used nucleases.\u003c\/p\u003e\n\u003ch3 data-mce-fragment=\"1\"\u003eSimple to Optimize in Cell Media\u003c\/h3\u003e\n\u003cp data-mce-fragment=\"1\"\u003eM-SAN HQ is uniquely formulated to excel in physiological pH conditions, offering high performance at the commonly used cell media pH of 7.4.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eWhile other nucleases often require more alkaline environments, M-SAN HQ stands out for its adaptability and effectiveness in cell media. It's the nuclease that truly aligns with your bioprocessing needs. (See Figure section)\u003c\/p\u003e\n\u003ch3 data-mce-fragment=\"1\"\u003eM-SAN HQ ELISA Kit\u003c\/h3\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThe M-SAN HQ ELISA Kit confirms the removal of M-SAN High Quality in bioprocessing and biomanufacturing applications with high accuracy: \u003c\/p\u003e\n\u003cul role=\"list\" data-mce-fragment=\"1\"\u003e\n\u003cli data-mce-fragment=\"1\"\u003e100% (±10%) Measuring range 0.47 – 7.50 ng\/ml\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003e100% (±20%) Measuring range 0.12 – 0.47 ng\/ml\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 data-mce-fragment=\"1\"\u003eFeatures:\u003c\/h3\u003e\n\u003cul role=\"list\" data-mce-fragment=\"1\"\u003e\n\u003cli data-mce-fragment=\"1\"\u003eFast: 1.5 – 2 hours\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eSensitive - Quantification range: 0.12 – 7.5 ng\/ml\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eAccurate\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eFlexible - 96-well plate in 8-well strip format\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"figures\" class=\"product_content\" data-mce-fragment=\"1\"\u003e\n\u003ch2 class=\"subheading is-orange is-product\" data-mce-fragment=\"1\"\u003eFIGURES\u003c\/h2\u003e\n\u003cdiv class=\"product_conditional-wrapper\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product-figure_list-wrapper w-dyn-list\" data-mce-fragment=\"1\"\u003e\n\u003cdiv role=\"list\" class=\"product-figure_list w-dyn-items\" data-mce-fragment=\"1\"\u003e\n\u003cdiv role=\"listitem\" class=\"product-figure_item w-dyn-item\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_card\" data-mce-fragment=\"1\"\u003e\n\u003ca href=\"https:\/\/www.arcticzymes.com\/product-details\/bioprocessing-with-salt-active-nucleases-physiological-conditions#\" class=\"figure_lightbox w-inline-block w-lightbox\" data-cmp-ab=\"2\" aria-label=\"open lightbox\" aria-haspopup=\"dialog\" data-mce-fragment=\"1\" data-mce-href=\"https:\/\/www.arcticzymes.com\/product-details\/bioprocessing-with-salt-active-nucleases-physiological-conditions#\" wfu-lightbox-captions=\"\"\u003e\u003cimg src=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/65bb50cf725563cc612780e0_fig%201%20M-SAN%20HQ.png\" loading=\"eager\" alt=\"M-SAN HQ (Physiological Conditions) - Optimum activity in solutions at physiological salinity\" sizes=\"(max-width: 479px) 83vw, (max-width: 767px) 90vw, (max-width: 991px) 88vw, 460px\" srcset=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/65bb50cf725563cc612780e0_fig%201%20M-SAN%20HQ-p-500.png 500w, https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/65bb50cf725563cc612780e0_fig%201%20M-SAN%20HQ-p-800.png 800w, https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/65bb50cf725563cc612780e0_fig%201%20M-SAN%20HQ-p-1080.png 1080w, https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/65bb50cf725563cc612780e0_fig%201%20M-SAN%20HQ-p-1600.png 1600w, https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/65bb50cf725563cc612780e0_fig%201%20M-SAN%20HQ.png 1920w\" class=\"figure_image\" data-cmp-ab=\"2\" data-cmp-info=\"10\" data-mce-fragment=\"1\" data-mce-src=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/65bb50cf725563cc612780e0_fig%201%20M-SAN%20HQ.png\" ref-key=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/65bb50cf725563cc612780e0_fig%201%20M-SAN%20HQ.png\"\u003e\u003c\/a\u003e\n\u003cdiv class=\"figure_heading-wrap\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_heading w-embed\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_heading\" data-mce-fragment=\"1\"\u003eFigure 1. Optimum activity in solutions at physiological salinity\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"figure_divider\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_divider-inner\" data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"figure_rte w-richtext\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eM-SAN High Quality has optimum activity between 125 - 250 mM NaCl, which correlates to the salt content in buffers with physiological salinity. The activity was measured at 37°C in a 25 mM Tris-HCl buffer, pH 7.4, 2.5 mM MgCl\u003csub data-mce-fragment=\"1\"\u003e2\u003c\/sub\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003eand varying concentrations of NaCl. Maximum activity was set to 100%.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv role=\"listitem\" class=\"product-figure_item w-dyn-item\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_card\" data-mce-fragment=\"1\"\u003e\n\u003ca href=\"https:\/\/www.arcticzymes.com\/product-details\/bioprocessing-with-salt-active-nucleases-physiological-conditions#\" class=\"figure_lightbox w-inline-block w-lightbox\" data-cmp-ab=\"2\" aria-label=\"open lightbox\" aria-haspopup=\"dialog\" data-mce-fragment=\"1\" data-mce-href=\"https:\/\/www.arcticzymes.com\/product-details\/bioprocessing-with-salt-active-nucleases-physiological-conditions#\" wfu-lightbox-captions=\"\"\u003e\u003cimg src=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64e73b27dadbbc18878b54c1_bio-figure-2.jpg\" loading=\"eager\" alt=\"M-SAN HQ (Physiological Conditions) - Outperforms commonly used nucleases at physiological salinity\" sizes=\"(max-width: 479px) 83vw, (max-width: 767px) 90vw, (max-width: 991px) 88vw, 460px\" srcset=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64e73b27dadbbc18878b54c1_bio-figure-2-p-500.jpg 500w, https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64e73b27dadbbc18878b54c1_bio-figure-2-p-800.jpg 800w, https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64e73b27dadbbc18878b54c1_bio-figure-2-p-1080.jpg 1080w, https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64e73b27dadbbc18878b54c1_bio-figure-2.jpg 1828w\" class=\"figure_image\" data-cmp-ab=\"2\" data-cmp-info=\"10\" data-mce-fragment=\"1\" data-mce-src=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64e73b27dadbbc18878b54c1_bio-figure-2.jpg\" ref-key=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64e73b27dadbbc18878b54c1_bio-figure-2.jpg\"\u003e\u003c\/a\u003e\n\u003cdiv class=\"figure_heading-wrap\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_heading w-embed\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_heading\" data-mce-fragment=\"1\"\u003eFigure 2. Outperforms commonly used nucleases at physiological salinity\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"figure_divider\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_divider-inner\" data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"figure_rte w-richtext\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003ePhysiological salinity is equivalent to approx. 150 mM NaCl. At this concentration of salt, M-SAN HQ is up to five-fold more efficient than commonly used nucleases with optimum performance in absence of salt. The activity was measured at 37°C in a 25 mM Tris-HCl buffer, pH 7.2, 5 mM MgCl\u003csub data-mce-fragment=\"1\"\u003e2\u003c\/sub\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003eand varying concentrations of NaCl. The same number of units of each nuclease was used.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv role=\"listitem\" class=\"product-figure_item w-dyn-item\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_card\" data-mce-fragment=\"1\"\u003e\n\u003ca href=\"https:\/\/www.arcticzymes.com\/product-details\/bioprocessing-with-salt-active-nucleases-physiological-conditions#\" class=\"figure_lightbox w-inline-block w-lightbox\" data-cmp-ab=\"2\" aria-label=\"open lightbox\" aria-haspopup=\"dialog\" data-mce-fragment=\"1\" data-mce-href=\"https:\/\/www.arcticzymes.com\/product-details\/bioprocessing-with-salt-active-nucleases-physiological-conditions#\" wfu-lightbox-captions=\"\"\u003e\u003cimg src=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64e73b7b7d897bf0c723588d_bio-figure-3.jpg\" loading=\"eager\" alt=\"M-SAN HQ (Physiological Conditions) - Highly compatible with physiological pH\" class=\"figure_image\" data-cmp-ab=\"2\" data-cmp-info=\"10\" data-mce-fragment=\"1\" data-mce-src=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64e73b7b7d897bf0c723588d_bio-figure-3.jpg\" ref-key=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64e73b7b7d897bf0c723588d_bio-figure-3.jpg\"\u003e\u003c\/a\u003e\n\u003cdiv class=\"figure_heading-wrap\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_heading w-embed\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_heading\" data-mce-fragment=\"1\"\u003eFigure 3. Highly compatible with physiological pH\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"figure_divider\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_divider-inner\" data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"figure_rte w-richtext\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eM-SAN HQ has optimal performance in the 7.2 - 8.7 pH range. This allows very high performance in most biological buffers. With a working range starting at pH 6.5, M-SAN HQ is also a candidate for DNA removal from insect cell media. The activity was measured at 37°C in a 25 mM Tris-HCl or Bis-Tris buffer at various pH, 2.5 mM MgCl\u003csub data-mce-fragment=\"1\"\u003e2\u003c\/sub\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003eand 150 mM NaCl. Activity measured at pH 7.7 was set to 100%.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv role=\"listitem\" class=\"product-figure_item w-dyn-item\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_card\" data-mce-fragment=\"1\"\u003e\n\u003ca href=\"https:\/\/www.arcticzymes.com\/product-details\/bioprocessing-with-salt-active-nucleases-physiological-conditions#\" class=\"figure_lightbox w-inline-block w-lightbox\" data-cmp-ab=\"2\" aria-label=\"open lightbox\" aria-haspopup=\"dialog\" data-mce-fragment=\"1\" data-mce-href=\"https:\/\/www.arcticzymes.com\/product-details\/bioprocessing-with-salt-active-nucleases-physiological-conditions#\" wfu-lightbox-captions=\"\"\u003e\u003cimg src=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64e73ee17d897bf0c7286c33_bio-figure-4.jpg\" loading=\"eager\" alt=\"M-SAN HQ (Physiological Conditions) - Superior performance at 37°C and above\" sizes=\"(max-width: 479px) 83vw, (max-width: 767px) 90vw, (max-width: 991px) 88vw, 460px\" srcset=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64e73ee17d897bf0c7286c33_bio-figure-4-p-500.jpg 500w, https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64e73ee17d897bf0c7286c33_bio-figure-4-p-800.jpg 800w, https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64e73ee17d897bf0c7286c33_bio-figure-4-p-1080.jpg 1080w, https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64e73ee17d897bf0c7286c33_bio-figure-4.jpg 1806w\" class=\"figure_image\" data-cmp-ab=\"2\" data-cmp-info=\"10\" data-mce-fragment=\"1\" data-mce-src=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64e73ee17d897bf0c7286c33_bio-figure-4.jpg\" ref-key=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64e73ee17d897bf0c7286c33_bio-figure-4.jpg\"\u003e\u003c\/a\u003e\n\u003cdiv class=\"figure_heading-wrap\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_heading w-embed\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_heading\" data-mce-fragment=\"1\"\u003eFigure 4. Superior performance at 37°C and above\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"figure_divider\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_divider-inner\" data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"figure_rte w-richtext\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eM-SAN HQ is highly efficient for digesting DNA at 37°C, and tolerate temperatures up to 50°C. The activity was measured in a 25 mM Tris-HCl buffer at pH 7.8 (@measurement temperature), 5 mM MgCl\u003csub data-mce-fragment=\"1\"\u003e2\u003c\/sub\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003eand 150 mM of NaCl. 37°C was set to 100% as this is the temperature used for defining the activity in Units.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv role=\"listitem\" class=\"product-figure_item w-dyn-item\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_card\" data-mce-fragment=\"1\"\u003e\n\u003ca href=\"https:\/\/www.arcticzymes.com\/product-details\/bioprocessing-with-salt-active-nucleases-physiological-conditions#\" class=\"figure_lightbox w-inline-block w-lightbox\" data-cmp-ab=\"2\" aria-label=\"open lightbox\" aria-haspopup=\"dialog\" data-mce-fragment=\"1\" data-mce-href=\"https:\/\/www.arcticzymes.com\/product-details\/bioprocessing-with-salt-active-nucleases-physiological-conditions#\" wfu-lightbox-captions=\"\"\u003e\u003cimg src=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64f9a7c00068f4ab01fbd6dc_efficient-residual-dna-fragmentation-2.png\" loading=\"eager\" alt=\"M-SAN HQ (Physiological Conditions) - Efficient Residual DNA Fragmentation\" sizes=\"(max-width: 479px) 83vw, (max-width: 767px) 90vw, (max-width: 991px) 88vw, 460px\" srcset=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64f9a7c00068f4ab01fbd6dc_efficient-residual-dna-fragmentation-2-p-500.png 500w, https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64f9a7c00068f4ab01fbd6dc_efficient-residual-dna-fragmentation-2.png 684w\" class=\"figure_image\" data-cmp-ab=\"2\" data-cmp-info=\"10\" data-mce-fragment=\"1\" data-mce-src=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64f9a7c00068f4ab01fbd6dc_efficient-residual-dna-fragmentation-2.png\" ref-key=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/64f9a7c00068f4ab01fbd6dc_efficient-residual-dna-fragmentation-2.png\"\u003e\u003c\/a\u003e\n\u003cdiv class=\"figure_heading-wrap\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_heading w-embed\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_heading\" data-mce-fragment=\"1\"\u003eFigure 5. Efficient Residual DNA Fragmentation\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"figure_divider\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_divider-inner\" data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"figure_rte w-richtext\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eGel analysis showing that  M-SAN HQ effectively reduces residual host cell DNA to under 8 nucleotides.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv role=\"listitem\" class=\"product-figure_item w-dyn-item\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_card\" data-mce-fragment=\"1\"\u003e\n\u003ca href=\"https:\/\/www.arcticzymes.com\/product-details\/bioprocessing-with-salt-active-nucleases-physiological-conditions#\" class=\"figure_lightbox w-inline-block w-lightbox\" data-cmp-ab=\"2\" aria-label=\"open lightbox\" aria-haspopup=\"dialog\" data-mce-fragment=\"1\" data-mce-href=\"https:\/\/www.arcticzymes.com\/product-details\/bioprocessing-with-salt-active-nucleases-physiological-conditions#\" wfu-lightbox-captions=\"\"\u003e\u003cimg src=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/65bb51abfe048ef40f25b7b7_Fig.%206%20M-SAN%20HQ.png\" loading=\"eager\" alt=\"M-SAN HQ (Physiological Conditions) - M-SAN HQ outperforms other nucleases in removal of host-cell DNA from HEK 293 cells directly in cell media\" sizes=\"(max-width: 479px) 83vw, (max-width: 767px) 90vw, (max-width: 991px) 88vw, 460px\" srcset=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/65bb51abfe048ef40f25b7b7_Fig.%206%20M-SAN%20HQ-p-500.png 500w, https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/65bb51abfe048ef40f25b7b7_Fig.%206%20M-SAN%20HQ.png 657w\" class=\"figure_image\" data-cmp-ab=\"2\" data-cmp-info=\"10\" data-mce-fragment=\"1\" data-mce-src=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/65bb51abfe048ef40f25b7b7_Fig.%206%20M-SAN%20HQ.png\" ref-key=\"https:\/\/assets-global.website-files.com\/64d5ee31f6ef966121388e81\/65bb51abfe048ef40f25b7b7_Fig.%206%20M-SAN%20HQ.png\"\u003e\u003c\/a\u003e\n\u003cdiv class=\"figure_heading-wrap\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_heading w-embed\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_heading\" data-mce-fragment=\"1\"\u003eFigure 6. M-SAN HQ outperforms other nucleases in removal of host-cell DNA from HEK 293 cells directly in cell media\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"figure_divider\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"figure_divider-inner\" data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"figure_rte w-richtext\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eM-SAN High Quality has optimal activity around physiological conditions, which makes it ideal for DNA removal directly in mammalian cell media In this case, HEK 293 cells were grown in DMEM for 48 hrs before nuclease treatment directly in medium (75 U\/ml nuclease). The medium was supplemented with Mg\u003csup data-mce-fragment=\"1\"\u003e2+\u003c\/sup\u003e. to 5 mM. Remaining DNA after 1 hr incubation at 37°C was quantified using Quant-iT™ PicoGreen™ dsDNA Assay Kit.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"properties\" class=\"product_content\" data-mce-fragment=\"1\"\u003e\n\u003ch2 class=\"subheading is-orange is-product\" data-mce-fragment=\"1\"\u003ePROPERTIES\u003c\/h2\u003e\n\u003cdiv class=\"product_table-wrap\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product_table-item\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"margin-top _20px w-richtext\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"w-embed\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product=table\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product-row\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product-cell-heading\" data-mce-fragment=\"1\"\u003e\n\u003cdiv data-mce-fragment=\"1\"\u003eSource\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-cell-data\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product-rte w-richtext\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eRecombinantly produced in Pichia pastoris\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-row\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product-cell-heading\" data-mce-fragment=\"1\"\u003e\n\u003cdiv data-mce-fragment=\"1\"\u003eMolecular weight\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-cell-data\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product-rte w-richtext\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003e24.5 kDa\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-row\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product-cell-heading\" data-mce-fragment=\"1\"\u003e\n\u003cdiv data-mce-fragment=\"1\"\u003eProtein Purity\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-cell-data\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product-rte w-richtext\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u0026gt; 99% by SDS-PAGE analysis\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-row\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product-cell-heading\" data-mce-fragment=\"1\"\u003e\n\u003cdiv data-mce-fragment=\"1\"\u003eIsoelectric point\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-cell-data\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product-rte w-richtext\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003e8.62\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-row\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product-cell-heading\" data-mce-fragment=\"1\"\u003e\n\u003cdiv data-mce-fragment=\"1\"\u003eUnit Definition\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-cell-data\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product-rte w-richtext\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eOne unit is defined as the amount of enzyme that causes a ΔA260 = 1.0 in 30 minutes at 37° in 25 mM Tris-HCl pH 7.6 (@25°C), 2.5 mM MgCl2, 150 mM NaCl, and 50 μg\/ml calf thymus DNA.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-row\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product-cell-heading\" data-mce-fragment=\"1\"\u003e\n\u003cdiv data-mce-fragment=\"1\"\u003eSpecificity\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-cell-data\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product-rte w-richtext\" data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eNonspecific endonuclease cleaving single and double stranded DNA and RNA.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-row\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product-cell-heading\" data-mce-fragment=\"1\"\u003e\n\u003cdiv data-mce-fragment=\"1\"\u003eWorking ranges\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-cell-data\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product-rte w-richtext\" data-mce-fragment=\"1\"\u003e\n\u003cul data-mce-fragment=\"1\"\u003e\n\u003cli data-mce-fragment=\"1\"\u003eTemperature: 20 – 50°C, optimal: 36 – 50°C\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eSalt concentrations (NaCI): 10 – 500 mM, optimal: 125 mM – 250 mM\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eMg2+: \u0026gt; 0.5 mM is required for activity, optimal: 4 – 15 mM\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003epH: 6.5 – 9.5, optimal: 7.2 – 8.7\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-mce-fragment=\"1\"\u003eNote: The working range is defined as above 10% activity and optimal range as above 80% activity.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-row\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product-cell-heading\" data-mce-fragment=\"1\"\u003e\n\u003cdiv data-mce-fragment=\"1\"\u003eTolerance to typical buffer additives\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-cell-data\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"product-rte w-richtext\" data-mce-fragment=\"1\"\u003e\n\u003cul data-mce-fragment=\"1\"\u003e\n\u003cli data-mce-fragment=\"1\"\u003eDTT and other reducing agents may inactivate M-SAN HQ\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eUrea: Not recommended\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eEDTA: Not recommended\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Arcticzymes","offers":[{"title":"Default Title","offer_id":44817025073376,"sku":"70950","price":0.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/6536bb563a16e78c26dd0ad8_M-SAN.webp?v=1708455123","url":"https:\/\/rndmate.com\/products\/m-san-hq-25-25ku-1-ml","provider":"알앤디메이트","version":"1.0","type":"link"}