{"product_id":"mkp-1-phospho-ser359-polyclonal-antibody-bt-lab","title":"MKP-1(Phospho Ser359) Polyclonal Antibody","description":"\u003cp\u003eThe expression of DUSP1 gene is induced in human skin fibroblasts by oxidative\/heat stress and growth factors.  It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr\/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus.  The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues.  Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes.  Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferati\u003c\/p\u003e\n\u003cp\u003eThe MKP-1(Phospho Ser359) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of MKP-1 protein phosphorylated at Ser359 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.\u003cbr\u003e\u003cbr\u003eMKP-1, also known as MAP kinase phosphatase-1, plays a crucial role in regulating the activity of mitogen-activated protein kinases (MAPKs). Phosphorylation of MKP-1 at Ser359 has been implicated in the modulation of its enzymatic activity, leading to the fine-tuning of MAPK signaling pathways.\u003cbr\u003e\u003cbr\u003eThe MKP-1(Phospho Ser359) Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and selectivity, enabling accurate and reliable detection of phosphorylated MKP-1 protein in complex biological samples.\u003cbr\u003e\u003cbr\u003eThis antibody is manufactured using high-quality materials and stringent quality control measures to ensure batch-to-batch consistency and reproducibility. It is supplied as a liquid formulation, ready for immediate use, and is compatible with a wide range of experimental conditions.\u003cbr\u003e\u003cbr\u003eResearchers and scientists studying MAPK signaling pathways and the role of MKP-1 in cellular processes will greatly benefit from the MKP-1(Phospho Ser359) Polyclonal Antibody. Its exceptional performance, reliability, and specificity make it an indispensable tool for elucidating the intricate mechanisms underlying cellular signaling events.\u003cbr\u003e\u003cbr\u003ePlease note that this product is for research use only and is not intended for diagnostic or therapeutic purposes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":42359144448224,"sku":"BT-AP11356","price":275.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/BT_Lab_f9770b7d-36aa-4b85-96aa-8c7dfcc40048.png?v=1644571601","url":"https:\/\/rndmate.com\/products\/mkp-1-phospho-ser359-polyclonal-antibody-bt-lab","provider":"알앤디메이트","version":"1.0","type":"link"}