{"product_id":"msk1-phospho-ser376-polyclonal-antibody-bt-lab","title":"MSK1(Phospho Ser376) Polyclonal Antibody","description":"\u003cp\u003eCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Appears to be activated by multiple phosphorylations on threonine and serine residues. ERK1\/2 and MAPK14\/p38-alpha may play a role in this process.,Serine\/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos\/FOS and c-jun\/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).,miscellaneous:Enzyme activity requires the presence of both kinase domains.,PTM:Ser-376 and Thr-581 phosphorylation is required for kinase activity. Ser-376 and Ser-212 are autophosphorylated by the C-terminal kinase domain, and their phosphorylation is essential for the Catalytic activity of the N-terminal kinase domain.,Belongs to the protein kinase superfamily. AGC Ser\/Thr protein kinase family. S6 kinase subfamily.,Contains 1 AGC-kinase C-terminal domain.,Contains 2 protein kinase domains.,subcellular location:Predominantly nuclear. Partially cytoplasmic.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14\/p38-alpha. Activated RPS6KA5 associates with and phosphorylates the NF-kappa-B p65 subunit RELA.,tissue specificity:Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.,\u003c\/p\u003e\n\u003cp\u003eThe MSK1(Phospho Ser376) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of MSK1 protein phosphorylated at Ser376. This antibody is produced using state-of-the-art techniques and exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThe MSK1 protein plays a crucial role in cellular signaling pathways, particularly in the regulation of gene expression and cell proliferation. Phosphorylation of MSK1 at Ser376 is known to be involved in the activation of downstream signaling cascades, leading to the modulation of various cellular processes.\u003cbr\u003e\u003cbr\u003eWith its high affinity and specificity towards the phosphorylated form of MSK1, this polyclonal antibody enables accurate and reliable detection of Ser376 phosphorylation levels. Its exceptional sensitivity allows for the detection of low abundance phosphorylated MSK1, making it an ideal tool for both basic research and clinical applications.\u003cbr\u003e\u003cbr\u003eThe MSK1(Phospho Ser376) Polyclonal Antibody is supplied as a ready-to-use solution, ensuring convenience and ease of use. It has been extensively validated and optimized to provide consistent and reproducible results. Additionally, it exhibits minimal cross-reactivity with non-phosphorylated MSK1 and other related proteins, ensuring reliable and specific detection.\u003cbr\u003e\u003cbr\u003eIn summary, the MSK1(Phospho Ser376) Polyclonal Antibody is a highly reliable and sensitive tool for the detection and quantification of phosphorylated MSK1 at Ser376. Its exceptional performance and specificity make it an invaluable asset for researchers and clinicians working in the field of cellular signaling and gene expression regulation.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":42359149953248,"sku":"BT-AP11545","price":275.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/BT_Lab_b4d415f7-529a-4fe2-b004-ce4b9fdf83e6.png?v=1644579449","url":"https:\/\/rndmate.com\/products\/msk1-phospho-ser376-polyclonal-antibody-bt-lab","provider":"알앤디메이트","version":"1.0","type":"link"}