{"product_id":"neu-phospho-tyr1221-y1222-polyclonal-antibody-bt-lab","title":"Neu(Phospho Tyr1221\/Y1222) Polyclonal Antibody","description":"\u003cp\u003eThis gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654\/Ile655, shown here. Amplification and\/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding d\u003c\/p\u003e\n\u003cp\u003eThe Neu(Phospho Tyr1221\/Y1222) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Neu protein phosphorylated at Tyr1221 and Tyr1222 residues. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target antigen.\u003cbr\u003e\u003cbr\u003eThe Neu protein, also known as ErbB2 or HER2, is a member of the epidermal growth factor receptor (EGFR) family and plays a crucial role in cell growth, differentiation, and survival. Phosphorylation of Neu at Tyr1221 and Tyr1222 residues is known to regulate its signaling pathway and is associated with various pathological conditions, including cancer.\u003cbr\u003e\u003cbr\u003eThis polyclonal antibody is rigorously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunohistochemistry. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated Neu protein in complex biological samples.\u003cbr\u003e\u003cbr\u003eThe Neu(Phospho Tyr1221\/Y1222) Polyclonal Antibody is supplied as a liquid formulation, ready to use for immediate experimentation. It is provided in a convenient size, ensuring cost-effectiveness and minimizing wastage.\u003cbr\u003e\u003cbr\u003eWith its exceptional performance and reliability, this antibody is an indispensable tool for researchers and scientists studying the role of Neu phosphorylation in various cellular processes and diseases.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":42359162831072,"sku":"BT-AP11822","price":275.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/BT_Lab_a05f4c12-a6ac-41b8-9755-a9c12c673255.png?v=1644566899","url":"https:\/\/rndmate.com\/products\/neu-phospho-tyr1221-y1222-polyclonal-antibody-bt-lab","provider":"알앤디메이트","version":"1.0","type":"link"}