{"product_id":"new-product-394331","title":"Dynactin 2 (L371) polyclonal antibody","description":"\u003cp\u003eDynactin is a multisubunit complex that functions as a binding partner for the Dynein microtubule motor. Dynactin-Dynein binding may be required for most, if not all, cytoplasmic Dynein-driven activities and is thought to contribute to the functional diversity of Dynein. Dynactin 2, also known as DCTN2, Dynamitin or DCTN50, is a peripheral membrane protein that is one of many subunits in the Dynactin complex. Like other Dynactin subunits, Dynactin 2 mediates Dynein-organelle binding and helps to regulate chromosome alignment during prometaphase and spindle organization during mitosis. Overexpression of Dynactin 2 disrupts the Dynactin-Dynein complex, thus inhibiting retrograde axonal transport and causing motor neuron degeneration. Additionally, overexpression of Dynactin 2 may disrupt the cell cycle and lead to osteosarcoma, suggesting a possible role for Dynactin 2 in carcinogenesis\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":44092000338144,"sku":"BS1271","price":325.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/bioWORLD-Logo-New_1617713956_905c2b90-85d2-469a-870b-d01da6fcb362.png?v=1689710373","url":"https:\/\/rndmate.com\/products\/new-product-394331","provider":"알앤디메이트","version":"1.0","type":"link"}