{"product_id":"new-product-394347","title":"PML (P39) polyclonal antibody","description":"\u003cp\u003eThe PML protein is a zinc finger transcription factor expressed as three major transcription products due to alternative splicing. The gene encoding human PML maps to chromosome 15q22. The t(15;17) (q22;q11.2-q12) chromosomal trans-location of the retinoic acid receptor α (RARα) gene occurs in virtually all cases of acute promyelocytic leukemia and results in the expression of a PML\/RARα chimeric protein. Myeloid precursor cells expressing the PML\/ RARα chimera fail to differentiate and exhibit an increased growth rate consequent to diminished apoptosis. PML\/RARα transforms myeloid precursors by recruiting the nuclear co-repressor (N-CoR)-histone deacetylase complex that is essential to retinoic acid-dependent myeloid differentiation. PML\/ RARα also recruits DNA methyltransferases in order to induce gene hypermethylation and silencing, which ultimately facilitates leukemogenesis.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human","offer_id":44092000862432,"sku":"BS1296","price":325.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/bioWORLD-Logo-New_1617713956_4ec783b8-7ad5-4070-93e9-8d7b88cfbfdb.png?v=1689710407","url":"https:\/\/rndmate.com\/products\/new-product-394347","provider":"알앤디메이트","version":"1.0","type":"link"}