{"product_id":"new-product-394641","title":"HAT1 polyclonal antibody","description":"\u003cp\u003eIn the intact cell, DNA closely associates with histones and other nuclear\u003cbr\u003e\nproteins to form chromatin. The remodeling of chromatin is believed to be\u003cbr\u003e\na critical component of transcriptional regulation and a major source of this\u003cbr\u003e\nremodeling is brought about by the acetylation of nucleosomal histones.\u003cbr\u003e\nAcetylation of lysine residues in the amino-terminal tail domain of histone\u003cbr\u003e\nresults in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including\u003cbr\u003e\nGCN5, PCAF (p300\/CBP-associated factor), p300\/CBP, HAT1 and the TFIID\u003cbr\u003e\nsubunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2\u003cbr\u003e\n(also designated RPD3) and HDAC3-6 have been identified as histone\u003cbr\u003e\ndeacetylases.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"l\/1ml \/ Rabbit \/ Human,Rat,Mouse","offer_id":44092018688224,"sku":"BS1650","price":325.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/bioWORLD-Logo-New_1617713956_56744f74-22f0-41bf-bdd6-9b8035419ce4.png?v=1689711077","url":"https:\/\/rndmate.com\/products\/new-product-394641","provider":"알앤디메이트","version":"1.0","type":"link"}