{"product_id":"new-product-394720","title":"IGF-2R (F2480) polyclonal antibody","description":"\u003cp\u003eThe mannose 6-phosphate\/insulin-like growth factor II receptor, IGF-IIR (also designated M6P\/IGF2R), is an ubiquitously expressed integral glycoprotein. By binding glycoproteins through two of its extracytoplasmic domains, IGF-IIR mediates the activation of TGFβ1 (a growth inhibitor), the degradation of IGF-II and the transport of lysosomal enzymes. Subsequently, IGF-IIR can form oligomeric complexes, which increase the affinity of IGF-IIR for lysosomal enzymes. Unlike IGF-IR, IGF-IIR does not potentiate the signaling of IGF-I or IGF-II, which have mitogenic, cell survival and insulin-like effects. Therefore,IGF-IIR is characterized as a tumor suppressor. Furthermore, the IGF-IIR gene is located on chromosome 6q26, which is commonly mutated or deleted in several human cancers.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":44092024914144,"sku":"BS1755","price":325.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/bioWORLD-Logo-New_1617713956_5ad267da-bbe6-4696-b89e-860ac6d1f4d6.png?v=1689711255","url":"https:\/\/rndmate.com\/products\/new-product-394720","provider":"알앤디메이트","version":"1.0","type":"link"}