{"product_id":"new-product-395105","title":"PEBP2β (R33) polyclonal antibody","description":"\u003cp\u003eThe transcription factor Polyomavirus enhancer binding protein 2 (PEBP2), also designated Osf2 (Osteoblast-specific transcription factor), CBFA1 (Core Binding Factor) and AML3 (Acute myeloid leukemia), is composed of two subunits, α and β, which are essential for the regulation of hematopoiesis and osteogenesis. The PEBP2α subunits, PEBP2αA, PEBP2αB and PEBP2αC, are encoded by three RUNX genes, all of which contain a 128-amino acid region homologous to the highly conserved Drosophila segmentation gene, runt. This region is involved in DNA binding and heterodimerization with the regulatory β subunit, which facilitates DNA binding of the α subunit. Both subunits are required for in vivo function; the disruption of either gene results in a lack of definitive hematopoiesis followed by embryo death in utero due to hemorrhage in the central nervous system.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":44092047687904,"sku":"BS2307","price":325.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/bioWORLD-Logo-New_1617713956_68ce912b-975e-462f-8931-f476f60c0c5f.png?v=1689712126","url":"https:\/\/rndmate.com\/products\/new-product-395105","provider":"알앤디메이트","version":"1.0","type":"link"}