{"product_id":"new-product-395537","title":"Cerebral 1 (L310) polyclonal antibody","description":"\u003cp\u003eCerebral 1 also called hucep-1, KIAA0409 or RRP8, is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+\/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":44092071444704,"sku":"BS3101","price":325.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/bioWORLD-Logo-New_1617713956_b6074d0e-dc8d-40ce-b7bc-ea9631b3dbb5.png?v=1689713072","url":"https:\/\/rndmate.com\/products\/new-product-395537","provider":"알앤디메이트","version":"1.0","type":"link"}