{"product_id":"new-product-395940","title":"Ataxin-2 (F774) polyclonal antibody","description":"\u003cp\u003eAtaxin-2, the gene product of the human spinocerebellar ataxia type 2 (SCA2\/ATXN2) gene, is a basic protein with two domains (Sm1 and Sm2) implicated in RNA splicing and protein interaction. Ataxin-2 interacts with a putative RNA-binding protein ataxin-2-binding-protein 1 (A2BP1), which is expressed in muscle and brain. Ataxin-2 is ubiquitously expressed with highest levels in the cytoplasm of Purkinje cells. Both A2BP1 and ataxin-2 are localized to the trans-Golgi network. Mice expressing ataxin-2 with polyglutamine show progressive functional deficits accompanied by loss of Purkinje cell dendritic arbor and eventually loss of Purkinje cells. In conclusion, expansion of ataxin-2 results in spinocerebellar ataxia type 2, which affects the cerebellum and other areas of the central nervous system.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human","offer_id":44092099723488,"sku":"BS3811","price":325.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/bioWORLD-Logo-New_1617713956_2696fa4c-087f-470a-9977-c351b80919fd.png?v=1689713971","url":"https:\/\/rndmate.com\/products\/new-product-395940","provider":"알앤디메이트","version":"1.0","type":"link"}