{"product_id":"new-product-396025","title":"ERα (P124) polyclonal antibody","description":"\u003cp\u003eThe estrogen receptor-alpha (ER) is a broadly expressed transcription factor which controls a number of genes involved in cellular differentiation and proliferation. ER contains two transcriptionally active domains: the N-terminal domain (AF1) is constitutively active, while the C-terminal domain (AF-2) is hormone-dependent. ER is subject to post-translational modification, including phosphorylation of serine residues 104, 106, 118, and 167. This antibody specifically recognizes human estrogen receptor-alpha when phosphorylated at serine 167, a site which influences AF-1 dependent transcriptional activity. This phosphorylation is catalyzed by the MAPK pathway, potentially through the 90 kDa ribosomal S6 kinase (pp90rsk1). Serine 167 is also a consensus Akt substrate.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":44092131475680,"sku":"BS5567","price":325.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/bioWORLD-Logo-New_1617713956_4e0e0c7c-506d-4b50-a84e-5fefadae6207.png?v=1689715255","url":"https:\/\/rndmate.com\/products\/new-product-396025","provider":"알앤디메이트","version":"1.0","type":"link"}