{"product_id":"new-product-396807","title":"IL3RA polyclonal antibody","description":"\u003cp\u003eIL3RA\/CD123 is the alpha subunit of an IL-3 receptor that also contains the common beta chain (βc) shared with receptors for other cytokines. IL3RA\/CD123 alone binds to IL-3 with high specificity but low affinity and it does not transduce intracellular signaling, while βc alone does not bind to IL-3 appreciably. Together, IL3RA\/CD123 and βc form the functional high-affinity receptor for IL-3. IL3RA\/CD123 is mainly expressed on the hematopoietic progenitor cells, primarily the granulocytic and monocytic linages . IL3RA\/CD123 is highly expressed on leukemic stem cells in the majority of AML (acute myeloid leukemia) patients and is correlated with poor prognosis. In addition, overexpression of IL3RA\/CD123 has also been reported for other hematopoietic malignancies. It is considered as a valuable therapeutic target for these malignancies.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Rat,Mouse","offer_id":44092179284192,"sku":"BS60620","price":325.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/bioWORLD-Logo-New_1617713956_e61fae7c-d5da-4b02-aad2-e42ae1085bfe.png?v=1689717241","url":"https:\/\/rndmate.com\/products\/new-product-396807","provider":"알앤디메이트","version":"1.0","type":"link"}