{"product_id":"new-product-396969","title":"A2M polyclonal antibody","description":"\u003cp\u003eα-2-Macroglobulin (α-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, α-2M was characterized as a pan-proteinase inhibitor thatwas able to “bait” proteinases into cleaving specific peptide sequences on α-2M. This interaction induces a conformational change in α-2M, thus enabling it to “trap”the proteinase and inhibit its further activity. Subsequently, α-2M has also been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor β (TGFβ) in serumis primarily bound to α-2M,which renders TGFβ inactive. α-2M also binds to IL-6 and, thereby, increasesthe concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved inmediating the inflammatory cascade. Mutations and deletions in the gene encoding α-2M are associated with an increased incidence of Alzheimer’s Disease (AD),which isconsistent with the role of α-2M inmediating the clearance and degradation of Aβ, the major component of β-Amyloid deposits accumulated during AD.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":44092191736032,"sku":"BS60859","price":325.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/bioWORLD-Logo-New_1617713956_12be35ec-da52-4367-b41d-dea36735ec0b.png?v=1689717659","url":"https:\/\/rndmate.com\/products\/new-product-396969","provider":"알앤디메이트","version":"1.0","type":"link"}