{"product_id":"new-product-403071","title":"HSD17B1 polyclonal antibody","description":"\u003cp\u003e17b-hydroxysteroid dehydrogenase type 1 (17b-HSD) catalyzes the final step in the formation of estradiol and testosterone from estrone and androstenedione, respectively. Ovarian granulosa cells and breast tissue both express 17b-HSD. Other tissues that express 17b-HSD include testis, placenta, uterus, prostate and adipose tissue. 17b-HSD functions as a homodimer and prefers NADP(H) over NAD(H) for oxidation and reduction. The gene encoding human 17b-HSD maps to chromosome 17q12-q21. The importance of 17b-HSD to estradiol production suggests the specific inhibition of 17b-HSD may aid in breast cancer therapy. Breast cancer patients with an amplification of 17b-HSD expression statistically have a worse outcome than those without. 17b-HSD amplification in tamoxifen-treated patients correlates to decreased breast cancer survival.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":44092449161440,"sku":"BS72641","price":408.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/products\/bioWORLD-Logo-New_1617713956_d356f71e-6137-4d33-bea1-3a7ea92119ed.png?v=1689729708","url":"https:\/\/rndmate.com\/products\/new-product-403071","provider":"알앤디메이트","version":"1.0","type":"link"}