{"product_id":"new-product-814724","title":"NCF4\/p40-phox Rabbit mAb","description":"\u003cp\u003eThe protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2\/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1\/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":46092102533344,"sku":"A0935","price":368.0,"currency_code":"KRW","in_stock":true}],"url":"https:\/\/rndmate.com\/products\/new-product-814724","provider":"알앤디메이트","version":"1.0","type":"link"}