{"product_id":"nsj-f42992-0-08ml","title":"NPC1 Antibody \/ Niemann Pick C1, 0.08 ml","description":"\u003cp\u003eThis gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal\/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal\/lysosomal compartments.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.08 ml","offer_id":48538415399136,"sku":"F42992-0.08ML","price":205.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_8a3b9b7c-c1b5-477d-a580-93131a0b63f1.jpg?v=1768362090","url":"https:\/\/rndmate.com\/products\/nsj-f42992-0-08ml","provider":"알앤디메이트","version":"1.0","type":"link"}