{"product_id":"nsj-f43048-0-4ml","title":"SMAD3 Antibody, 0.4 ml","description":"\u003cp\u003eSMAD3 is a receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by \u003ca href=\"..\/search_result.php?search_txt=tgfb\"\u003eTGF-beta\u003c\/a\u003e (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the \u003ca href=\"..\/search_result.php?search_txt=smad3\"\u003eSMAD3\u003c\/a\u003e\/\u003ca href=\"..\/search_result.php?search_txt=smad4\"\u003eSMAD4\u003c\/a\u003e complex, activates transcription. Also can form a SMAD3\/SMAD4\/JUN\/FOS complex at the AP-1\/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF- mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the \u003ca href=\"..\/search_result.php?search_txt=14-3-3\"\u003e14-3-3\u003c\/a\u003e protein YWHAQ which acts as a negative regulator. [UniProt]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.4 ml","offer_id":48538414383328,"sku":"F43048-0.4ML","price":439.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_26972f42-e7df-4995-899d-bd927d984ea1.jpg?v=1768362069","url":"https:\/\/rndmate.com\/products\/nsj-f43048-0-4ml","provider":"알앤디메이트","version":"1.0","type":"link"}