{"product_id":"nsj-f52197-0-08ml","title":"Cyclin D2 Antibody (CCND2), 0.08 ml","description":"\u003cp\u003eRegulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)\/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB\/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2\/CDK4\/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.08 ml","offer_id":48538121961696,"sku":"F52197-0.08ML","price":205.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_706de7a9-34f5-4e83-a0ad-6baa16b1c2ca.jpg?v=1768358506","url":"https:\/\/rndmate.com\/products\/nsj-f52197-0-08ml","provider":"알앤디메이트","version":"1.0","type":"link"}