{"product_id":"nsj-fy12019-100ug","title":"GHRHR Antibody \/ Growth hormone releasing hormone receptor, 100 ug","description":"\u003cp\u003eGHRHR antibody detects Growth hormone releasing hormone receptor, encoded by the GHRHR gene. Growth hormone releasing hormone receptor is a G protein-coupled receptor expressed in the anterior pituitary, where it mediates responses to growth hormone releasing hormone. GHRHR antibody provides researchers with a tool to study endocrine signaling, growth regulation, and disease mechanisms involving pituitary hormone production.\u003cbr\u003e\u003cbr\u003eGrowth hormone releasing hormone receptor activates adenylate cyclase and cAMP signaling pathways upon binding its ligand. Research using GHRHR antibody has shown that this activation stimulates growth hormone synthesis and secretion. Growth hormone then regulates somatic growth, metabolism, and tissue repair through downstream IGF-1 production. This axis is essential for normal growth and metabolic homeostasis.\u003cbr\u003e\u003cbr\u003eStudies with GHRHR antibody have revealed that mutations in GHRHR cause isolated growth hormone deficiency. This condition is characterized by short stature, delayed growth, and impaired metabolic adaptation. Mutations that disrupt receptor folding, trafficking, or signaling result in insufficient growth hormone production, demonstrating the receptor's critical physiological role.\u003cbr\u003e\u003cbr\u003eBeyond growth deficiency, dysregulation of GHRHR signaling contributes to endocrine disease and cancer. Research using GHRHR antibody has shown that receptor variants are expressed in tumors such as pituitary adenomas and certain carcinomas. Aberrant signaling through GHRHR promotes proliferation and survival, linking it to oncogenic pathways. These findings highlight GHRHR as both a diagnostic marker and a potential therapeutic target.\u003cbr\u003e\u003cbr\u003eGHRHR antibody is widely used in immunohistochemistry, western blotting, and receptor binding assays. Immunohistochemistry highlights expression in pituitary tissue, western blotting quantifies receptor levels, and binding studies confirm functional activity. These applications make GHRHR antibody indispensable in endocrinology and oncology research.\u003cbr\u003e\u003cbr\u003eBy providing validated GHRHR antibody reagents, NSJ Bioreagents supports studies into pituitary signaling, growth hormone regulation, and disease. Detection of Growth hormone releasing hormone receptor provides researchers with insights into how endocrine pathways control growth and metabolism.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48537717113056,"sku":"FY12019","price":449.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_4151f80f-9ce8-44ac-906d-cf7aa0f8fc11.jpg?v=1768354346","url":"https:\/\/rndmate.com\/products\/nsj-fy12019-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}