{"product_id":"nsj-fy12065-100ug","title":"TDRD5 Antibody \/ Tudor domain-containing protein 5, 100 ug","description":"\u003cp\u003eTDRD5 antibody detects Tudor domain-containing protein 5, encoded by the TDRD5 gene. Tudor domain-containing protein 5 is a germ cell-specific protein that regulates piRNA pathway function, transposon silencing, and spermatogenesis. TDRD5 antibody provides researchers with a tool for studying reproductive biology, germline epigenetics, and fertility.\u003cbr\u003e\u003cbr\u003eTudor domain-containing protein 5 contains multiple Tudor domains that bind symmetrically dimethylated arginine residues on Piwi-interacting proteins and other components of the piRNA pathway. Research using TDRD5 antibody has shown that it localizes to nuage structures and intermitochondrial cement in germ cells, where it assembles piRNA-protein complexes. These complexes are critical for silencing transposable elements and protecting genome integrity in the germline.\u003cbr\u003e\u003cbr\u003eStudies with TDRD5 antibody have revealed that knockout models lacking TDRD5 display impaired spermatogenesis, defective piRNA processing, and male infertility. This demonstrates its essential role in germ cell development. TDRD5 works in concert with other Tudor domain proteins, such as TDRD1 and TDRD9, to coordinate piRNA biogenesis and transposon repression.\u003cbr\u003e\u003cbr\u003eDysfunction of Tudor domain-containing protein 5 has been associated with infertility and germline genome instability. Research using TDRD5 antibody has shown that disruption of piRNA regulation allows mobilization of retrotransposons, resulting in DNA damage and germ cell loss. These findings emphasize its protective function in the germline.\u003cbr\u003e\u003cbr\u003eTDRD5 antibody is widely applied in immunohistochemistry, immunofluorescence, and western blotting. Immunohistochemistry reveals expression in testis, immunofluorescence demonstrates localization in nuage and germ granules, and western blotting quantifies protein levels during germ cell development. These methods make TDRD5 antibody indispensable in reproductive biology research.\u003cbr\u003e\u003cbr\u003eBy supplying validated TDRD5 antibody reagents, NSJ Bioreagents supports studies into germline epigenetics, piRNA pathways, and fertility. Detection of Tudor domain-containing protein 5 provides researchers with insight into how germ cell proteins maintain genome stability and reproductive capacity.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48537715572960,"sku":"FY12065","price":449.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_116e8c8a-f760-4f84-a264-d795f47017d6.jpg?v=1768354286","url":"https:\/\/rndmate.com\/products\/nsj-fy12065-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}