{"product_id":"nsj-fy12088-100ug","title":"PHGDH Antibody \/ D-3-phosphoglycerate dehydrogenase, 100 ug","description":"\u003cp\u003ePHGDH antibody detects D-3-phosphoglycerate dehydrogenase, encoded by the PHGDH gene. D-3-phosphoglycerate dehydrogenase is a key enzyme in the serine biosynthesis pathway, catalyzing the conversion of 3-phosphoglycerate to 3-phosphohydroxypyruvate. PHGDH antibody provides researchers with a critical reagent for studying amino acid metabolism, cancer metabolism, and neurological disease.\u003cbr\u003e\u003cbr\u003eD-3-phosphoglycerate dehydrogenase is the first and rate-limiting enzyme of the phosphorylated pathway of serine biosynthesis. Research using PHGDH antibody has shown that it links glycolysis to serine and glycine production, supporting nucleotide, lipid, and redox metabolism. This central role in metabolic reprogramming makes PHGDH particularly important in rapidly dividing cells and cancer biology.\u003cbr\u003e\u003cbr\u003eStudies with PHGDH antibody have revealed that amplification and overexpression occur in multiple cancers, including melanoma, breast cancer, and glioma. Increased PHGDH expression enhances serine synthesis, fueling biosynthetic pathways that support tumor growth. Targeting PHGDH has therefore emerged as a potential therapeutic approach in oncology.\u003cbr\u003e\u003cbr\u003eBeyond cancer, research using PHGDH antibody has highlighted roles in neurodevelopment and inherited metabolic disorders. Mutations in PHGDH cause serine deficiency disorders, leading to microcephaly, psychomotor retardation, and seizures. These findings demonstrate the dual clinical relevance of PHGDH in both metabolic disease and cancer.\u003cbr\u003e\u003cbr\u003eDysregulation of D-3-phosphoglycerate dehydrogenase has also been linked to immune function, as serine metabolism influences lymphocyte proliferation and differentiation. Research using PHGDH antibody continues to uncover links between metabolism, immune responses, and disease progression.\u003cbr\u003e\u003cbr\u003ePHGDH antibody is widely used in western blotting, immunohistochemistry, and enzymatic activity assays. Western blotting quantifies enzyme expression in tumors and metabolic tissues, immunohistochemistry highlights localization in brain and cancer sections, and activity assays confirm catalytic function. These applications make PHGDH antibody indispensable for metabolic and cancer research.\u003cbr\u003e\u003cbr\u003eBy supplying validated PHGDH antibody reagents, NSJ Bioreagents supports studies into serine metabolism, cancer biology, and neurological disease. Detection of D-3-phosphoglycerate dehydrogenase provides researchers with insight into how amino acid metabolism supports physiology and pathology.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48537714131168,"sku":"FY12088","price":449.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_2fb63e87-a0d0-4735-99a0-4ea1a408c861.jpg?v=1768354259","url":"https:\/\/rndmate.com\/products\/nsj-fy12088-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}