{"product_id":"nsj-fy12153-100ul","title":"LFNG Antibody \/ Lunatic Fringe, 100 ul","description":"\u003cp\u003eLFNG antibody detects lunatic fringe, a glycosyltransferase that modifies Notch receptors and regulates Notch signaling pathways. LFNG belongs to the fringe family of glycosyltransferases, which add N-acetylglucosamine residues to O-fucose on epidermal growth factor-like repeats of Notch. This modification alters ligand binding specificity and modulates signaling outcomes critical for development and tissue homeostasis.\u003cbr\u003e\u003cbr\u003eResearch using LFNG antibody has highlighted the protein's role in embryogenesis. LFNG is required for somitogenesis, the process that establishes segmented structures in the developing embryo. Loss of LFNG function leads to defects in somitic patterning and skeletal abnormalities, demonstrating its importance in developmental timing. Beyond embryonic segmentation, LFNG also contributes to hematopoiesis, vascular development, and neural differentiation by fine-tuning Notch signaling activity.\u003cbr\u003e\u003cbr\u003eDysregulation of LFNG has been implicated in cancer and congenital disorders. Aberrant expression of LFNG can lead to uncontrolled Notch signaling, a hallmark of various malignancies including breast cancer and T-cell acute lymphoblastic leukemia. Reduced LFNG activity may also contribute to congenital scoliosis and vertebral malformations. Understanding how LFNG modifies Notch receptors provides insights into therapeutic targeting of developmental and cancer-related pathways.\u003cbr\u003e\u003cbr\u003eAntibodies against LFNG are validated for western blot, immunohistochemistry, and immunofluorescence. These tools enable researchers to study expression patterns in embryonic and adult tissues, as well as to evaluate changes in Notch pathway regulation. Clone-based antibodies ensure reliable detection of LFNG across experimental conditions.\u003cbr\u003e\u003cbr\u003eNSJ Bioreagents provides this LFNG antibody for developmental biology, cancer, and signaling research.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ul","offer_id":48537711608032,"sku":"FY12153","price":449.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_8c87895f-1eaf-4d14-b214-252df2fd7144.jpg?v=1768354178","url":"https:\/\/rndmate.com\/products\/nsj-fy12153-100ul","provider":"알앤디메이트","version":"1.0","type":"link"}