{"product_id":"nsj-fy12277-100ug","title":"HTATSF1 Antibody \/ HIV Tat-specific factor 1, 100 ug","description":"\u003cp\u003eHTATSF1 antibody detects HIV Tat-specific factor 1, encoded by the HTATSF1 gene on chromosome 17q21.31. HTATSF1 antibody is commonly used in transcription biology, RNA processing, and viral research. HTATSF1 was originally identified as a cellular factor required for HIV-1 Tat-mediated transcriptional activation. It is now recognized as a general transcription elongation factor that associates with RNA polymerase II and influences RNA splicing, elongation, and processing.\u003cbr\u003e\u003cbr\u003eStructurally, HTATSF1 is a nuclear protein containing RS-rich domains typical of splicing regulators, as well as multiple motifs for protein-protein and protein-RNA interactions. These domains allow HTATSF1 to associate with the transcription machinery and with spliceosomal components. Isoforms generated by alternative splicing may modulate transcriptional and splicing activities.\u003cbr\u003e\u003cbr\u003eFunctionally, HTATSF1 facilitates RNA polymerase II elongation by interacting with transcriptional elongation complexes and splicing factors. It coordinates co-transcriptional splicing, ensuring efficient coupling of RNA synthesis with processing. In the context of HIV infection, HTATSF1 enhances Tat-dependent transcriptional elongation, supporting viral replication. Researchers use HTATSF1 antibody to study transcription elongation, splicing regulation, and viral-host interactions.\u003cbr\u003e\u003cbr\u003eClinically, dysregulation of HTATSF1 has been implicated in cancer, where altered transcription elongation contributes to oncogenic gene expression. Because transcription elongation is critical for rapidly dividing cells, HTATSF1 is considered a potential therapeutic target. HTATSF1 also influences viral replication and could serve as a target for antiviral therapies. NSJ Bioreagents provides HTATSF1 antibody to support research in transcription biology, RNA processing, and infectious disease.\u003cbr\u003e\u003cbr\u003eExperimentally, HTATSF1 antibody is used in western blotting to detect the protein, in immunohistochemistry to examine nuclear expression in tissues, and in chromatin immunoprecipitation to analyze transcriptional elongation complexes. Co-immunoprecipitation with HTATSF1 antibody identifies interaction partners in the elongation and splicing machinery.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48537706463456,"sku":"FY12277","price":449.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_7bfbce3d-6bd4-4293-8223-17f9330884dc.jpg?v=1768354030","url":"https:\/\/rndmate.com\/products\/nsj-fy12277-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}