{"product_id":"nsj-fy12469-100ug","title":"LGALS3 Antibody \/ Galectin 3 \/ GAL3, 100 ug","description":"\u003cp\u003eLGALS3 antibody detects Galectin-3, a beta-galactoside-binding lectin involved in cell adhesion, immune modulation, apoptosis regulation, fibrosis, and tumor progression. Galectin-3 functions as both an intracellular regulator and an extracellular signaling molecule, mediating diverse processes such as inflammation, angiogenesis, and cell-matrix interaction. The LGALS3 antibody is extensively used in studies of cancer, cardiovascular disease, and immune disorders where Galectin-3 serves as a biomarker and functional effector in pathological remodeling.\u003cbr\u003e\u003cbr\u003eGalectin-3 is encoded by the LGALS3 gene located on human chromosome 14q22.3. The protein contains a carbohydrate recognition domain that binds beta-galactoside residues on glycoproteins and an N-terminal domain enabling oligomerization. This structure allows Galectin-3 to form lattices at the cell surface, influencing receptor clustering and signaling. It is expressed in epithelial cells, macrophages, fibroblasts, and endothelial cells, and can be secreted via a non-classical pathway into the extracellular space. Once outside the cell, it modulates adhesion and migration, contributing to wound healing and fibrosis.\u003cbr\u003e\u003cbr\u003eThe LGALS3 antibody is particularly useful for detecting Galectin-3 expression in tumor and fibrotic tissues. Western blot typically shows an ~26 kilodalton band, while immunostaining reveals cytoplasmic, nuclear, or membrane-associated localization depending on cellular context. Overexpression of Galectin-3 is associated with aggressive tumor phenotypes, including resistance to apoptosis and enhanced metastasis. Mechanistically, Galectin-3 interacts with cell-surface receptors such as integrins and growth factor receptors, amplifying signaling through the phosphoinositide 3-kinase\/AKT and transforming growth factor beta (TGF-beta) pathways. This dual role in intracellular survival signaling and extracellular communication underscores its complexity as a therapeutic target.\u003cbr\u003e\u003cbr\u003eBeyond oncology, Galectin-3 contributes to fibrotic progression in the heart, kidneys, and liver. It promotes fibroblast activation, collagen deposition, and tissue stiffening, leading to organ dysfunction. Elevated plasma Galectin-3 levels are now used clinically as a prognostic biomarker for heart failure. In immune regulation, Galectin-3 modulates macrophage polarization, promotes neutrophil adhesion, and suppresses T-cell receptor signaling, linking innate and adaptive immune responses. NSJ Bioreagents offers a validated LGALS3 antibody optimized for western blot, ELISA, flow cytometry, and immunohistochemistry, providing reliable detection of Galectin-3 for applications across cancer, inflammation, and fibrotic disease research.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48537699549408,"sku":"FY12469","price":449.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_1e7802bf-ba9e-4a0a-957e-1da007302233.jpg?v=1768353754","url":"https:\/\/rndmate.com\/products\/nsj-fy12469-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}