{"product_id":"nsj-fy12665-100ug","title":"STRIP1 Antibody \/ Striatin-interacting protein 1, 100 ug","description":"\u003cp\u003eSTRIP1 antibody detects Striatin-interacting protein 1, a core component of the STRIPAK complex that integrates signaling, cytoskeletal organization, and cell migration. STRIP1 acts as a scaffold linking the PP2A phosphatase complex with kinases, adaptors, and actin-regulating proteins. The STRIP1 antibody is widely used in cell signaling, neurobiology, and cancer research to study cytoskeletal remodeling, phosphatase signaling, and morphogenesis.\u003cbr\u003e\u003cbr\u003eSTRIP1 is encoded by the STRIP1 gene located on human chromosome 3q22.1. The protein is approximately 837 amino acids long and forms stable interactions with striatin, PP2A, MOB4, and kinases of the GCKIII family. STRIP1 localizes to both cytoplasmic and cortical compartments, particularly in regions of actin remodeling and cell junctions.\u003cbr\u003e\u003cbr\u003eThe STRIP1 antibody detects a 95 kilodalton protein by western blot and exhibits perinuclear and cortical staining by immunofluorescence microscopy. STRIP1 regulates the activity of PP2A-dependent phosphatase signaling pathways that control cell polarity, adhesion, and migration. It acts in concert with STRN3 and STRN4 to modulate kinases such as STK24 and STK25, thereby maintaining cytoskeletal balance and tissue architecture.\u003cbr\u003e\u003cbr\u003eDisruption of STRIP1 impairs cell migration and polarity, leading to developmental abnormalities and cancer metastasis. Studies show that loss of STRIP1 alters actin stress fiber organization and cell junction stability, while overexpression promotes invasive behavior in tumor cells. In neurons, STRIP1 contributes to dendritic spine morphogenesis and synaptic plasticity through modulation of PP2A and Rho GTPase signaling.\u003cbr\u003e\u003cbr\u003eBecause STRIP1 functions as a molecular integrator connecting phosphatase signaling with cytoskeletal regulation, it serves as a crucial factor in understanding morphogenesis and disease progression. NSJ Bioreagents provides a validated STRIP1 antibody optimized for its applications, supporting research into cytoskeletal dynamics, PP2A signaling, and cancer biology.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48537683034336,"sku":"FY12665","price":449.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_3bdbef13-2f84-4aec-acd9-53bb2ffdb821.jpg?v=1768353485","url":"https:\/\/rndmate.com\/products\/nsj-fy12665-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}