{"product_id":"nsj-fy12784-100ug","title":"SRARP Antibody \/ Steroid receptor-associated and regulated protein, 100 ug","description":"\u003cp\u003eSRARP antibody detects Steroid receptor-associated and regulated protein, a nuclear transcriptional regulator that modulates retinoic acid and estrogen receptor signaling. Encoded by the SRARP gene on chromosome 1p36.12, this protein functions as a transcriptional cofactor influencing gene expression during development and cellular differentiation. SRARP contains LXXLL motifs characteristic of nuclear receptor cofactors and acts as both a transcriptional regulator and target of steroid hormone pathways.\u003cbr\u003e\u003cbr\u003eSRARP is expressed in hormone-responsive tissues including the brain, ovary, testis, and endometrium. It interacts with nuclear receptors such as estrogen receptor alpha (ERalpha) and retinoic acid receptor (RAR), modulating transcriptional output in a ligand-dependent manner. Through these interactions, SRARP influences gene networks governing cell cycle progression, neurogenesis, and reproductive tissue differentiation. Its expression is hormonally regulated, increasing in response to estrogen and decreasing under conditions of hormone withdrawal.\u003cbr\u003e\u003cbr\u003eThe SRARP antibody is widely used in endocrinology, neurobiology, and developmental research to study transcriptional regulation and steroid receptor signaling. Western blot analysis typically identifies a 27 kilodalton band corresponding to SRARP, while immunofluorescence shows nuclear localization in hormone-responsive cells. This antibody enables characterization of SRARP's role in receptor signaling and target gene transcription.\u003cbr\u003e\u003cbr\u003eDysregulation of SRARP expression has been linked to altered reproductive function and hormone-dependent cancers, including breast and ovarian carcinoma. SRARP may function as a modulator balancing proliferative and differentiation signals in response to hormonal cues. The SRARP antibody provides a key reagent for exploring transcriptional networks influenced by steroid receptors. NSJ Bioreagents supplies this antibody validated for western blotting and immunohistochemistry, ensuring high sensitivity and reproducibility for hormone receptor research.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48537677955296,"sku":"FY12784","price":449.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_d3cf7add-4ec1-4388-9b3a-954bc21eaa0c.jpg?v=1768353321","url":"https:\/\/rndmate.com\/products\/nsj-fy12784-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}