{"product_id":"nsj-r30940-100ug","title":"TRAIL R2 Antibody (DR5), 100 ug","description":"\u003cp\u003eTNFRSF10B (Tumor necrosis factor receptor superfamily, member 10b) has many names, including DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL R2, KILLER\/DR5. The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10\/TRAIL\/APO-2L), and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b, that has been essential in the elucidation of the function of this gene in humans. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. By analysis of radiation hybrid panels, Walczak et al.(1997) mapped the gene to chromosome 8p22-p21. Northern blot analysis indicated that TRAIL R2 was expressed as a 4.4-kb mRNA in all tissues tested, with the highest levels of expression in peripheral blood lymphocytes, spleen, and ovary.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48536605720800,"sku":"R30940","price":449.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_445d1c61-beb4-48f7-a727-4cd80e4259ff.jpg?v=1768312531","url":"https:\/\/rndmate.com\/products\/nsj-r30940-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}