{"product_id":"nsj-r31002-100ug","title":"TRIF Antibody, 100 ug","description":"\u003cp\u003eTIR Domain-containing adaptor molecule 1, also known as TICAM1 or TRIF, is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. By genomic sequence analysis, Oshiumi et al.(2003) mapped the gene to chromosome 19p13.3. By coimmunoprecipitation analysis, Oshiumi et al.(2003) showed that the protein interacts specifically with \u003ca href=\"..\/search_result.php?search_txt=TLR3\"\u003eTLR3\u003c\/a\u003e, but not with other TLRs. Functional analysis showed that the association of TLR3 and TRIF mediates dsRNA activation of IFNB, through either \u003ca href=\"..\/search_result.php?search_txt=nfkb\"\u003eNFKB\u003c\/a\u003e, \u003ca href=\"..\/search_result.php?search_txt=ap1\"\u003eAP1\u003c\/a\u003e, or \u003ca href=\"..\/search_result.php?search_txt=irf3\"\u003eIRF3\u003c\/a\u003e. TRIF activation of NFKB was found to occur predominantly through \u003ca href=\"..\/search_result.php?search_txt=irak1\"\u003eIRAK1\u003c\/a\u003e rather than \u003ca href=\"..\/search_result.php?search_txt=irak2\"\u003eIRAK2\u003c\/a\u003e. siRNA blockage of the protein reduced IFNB production in response to dsRNA.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48536604082400,"sku":"R31002","price":449.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_bc41009f-e705-4c55-bf17-ce010dd367d7.jpg?v=1768312479","url":"https:\/\/rndmate.com\/products\/nsj-r31002-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}