{"product_id":"nsj-r31006-100ug","title":"CSF3R Antibody Colony Stimulating Factor 3 Receptor, 100 ug","description":"\u003cp\u003eColony-Stimulating Factor 3 Receptor, Granulocyte also known as GCSFR or CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. By in situ hybridization using human CSF3R cDNA as a probe, Inazawa et al.(1991) localized the gene to 1p35-p34.3. The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1\/2. Dong et al.(2001) reported that the C terminus of CSF3R is required for SHP1 downregulation of CSF3-induced STAT activation. The authors proposed that this mechanism inhibits cell proliferation and survival in response to CSF3.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48536603951328,"sku":"R31006","price":449.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_b6c6c03b-ad1c-4a24-8bd4-4a6454d8fa88.jpg?v=1768312474","url":"https:\/\/rndmate.com\/products\/nsj-r31006-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}