{"product_id":"nsj-r31198-100ug","title":"Proprotein Convertase 4 Antibody, 100 ug","description":"\u003cp\u003eProprotein Convertase, Subtilisin\/Kexin-Type, 4, is an enzyme that in humans is encoded by the PCSK4 gene. The gene was mapped to mouse chromosome 10, close to the adipsin locus and near the gene encoding anti-mullerian hormone. Qiu et al.(2005) found that aberrant processing of pro-IGF2 may be a cause of IUGR. PCSK4 cleaved pro-IGF2 to generate the intermediate processed form, IGF2(1-102). Mature IGF2(1-67), likely resulting from further processing by carboxypeptidases, is capable of activating invasive trophoblast cells through AKT phosphorylation. Inhibition of the protein by a PCSK4-specific inhibitor blocked pro-IGF2 processing and reduced trophoblast cell migration.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48536599068896,"sku":"R31198","price":449.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_9f184e2c-050c-40e5-976b-25d84c2177da.jpg?v=1768312301","url":"https:\/\/rndmate.com\/products\/nsj-r31198-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}