{"product_id":"nsj-r31515-100ug","title":"HSP90 alpha Antibody \/ HSP90AA1, 100 ug","description":"\u003cp\u003eHeat shock protein 90 is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. Inhibitors of it are investigated as anti-cancer drugs. Heat shock proteins, as a class, are among the most highly expressed cellular proteins across all species. HSP90 acts as a capacitor for morphologic evolution through epigenetic and genetic mechanisms. It is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, including HER2\/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53. Although it is highly expressed in most cells, HSP90 inhibitors selectively kill cancer cells compared to normal cells, and the the inhibitor 17-allylaminogeldanamycin (17-AAG) exhibited antitumor activity in preclinical models.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48536589467872,"sku":"R31515","price":449.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_e05cb909-63d2-4db0-9d69-1843e412b8c2.jpg?v=1768312017","url":"https:\/\/rndmate.com\/products\/nsj-r31515-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}