{"product_id":"nsj-r31750-100ug","title":"HSP60 Antibody \/ HSPD1, 100 ug","description":"\u003cp\u003eHSP60 is a member of the chaperonin class of protein factors, which include the Escherichia coli groEL protein and the Rubisco subunit-binding protein of chloroplasts. It acts as a costimulator of human regulatory CD4-positive\/CD25 -positive T cells, which inhibit lymphoproliferation and IFNG and TNF secretion by CD4-positive and CD8-positive T cells. HSP60 enhances Treg activity via TLR2, leading to activation of an intracellular signaling cascade that included p38, as well as inhibition of ERK phosphorylation. Suppression of target T cells is mediated by both cell-to-cell contact and by secretion of TGFB and IL10, and it leads to downregulation of ERK, \u003ca href=\"..\/search_result.php?search_txt=nfkb\"\u003eNFKB\u003c\/a\u003e, and \u003ca href=\"..\/search_result.php?search_txt=tbet\"\u003eTBET\u003c\/a\u003e expression. The self-molecule HSP60 can downregulate adaptive immune responses by upregulating Tregs through \u003ca href=\"..\/search_result.php?search_txt=tlr2\"\u003eTLR2\u003c\/a\u003esignaling.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":48536580260064,"sku":"R31750","price":449.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/9330\/8896\/files\/get_image_aafdab92-4e59-4bd8-821f-e9d1b2496d38.jpg?v=1768311730","url":"https:\/\/rndmate.com\/products\/nsj-r31750-100ug","provider":"알앤디메이트","version":"1.0","type":"link"}